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General Information
| Manuscript title | A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes. |
| PubMed ID | 23831062 |
| Journal | FEBS Letters |
| Year | 2013 |
| Authors | Kieran Smallbone, Hanan L. Messiha, Kathleen M. Carroll, Catherine L. Winder, Naglis Malys, Warwick B. Dunn, Ettore Murabito, Neil Swainston, Joseph O. Dada, Farid Khan, Pınar Pir, Evangelos Simeonidis, Irena Spasić, Jill Wishart, Dieter Weichart, Neil W. |
| Affiliations | Manchester Centre for Integrative Systems Biology, Manchester Institute of Biotechnology, The University of Manchester, UK |
| Keywords | Glycolysis, Systems biology, Enzyme kinetic, Isoenzyme, Modelling |
| Full text article |
Smallbone_2013.pdf
|
| Project name | not specified |
| Data used for | Model validation |
Model Information
| Model name | smallbone18 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Organism | Saccharomyces cerevisiae | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Associated Data EntryID |
Saccharomyces cerevisiae (Data EntryID:99) Saccharomyces cerevisiae (Data EntryID:98) Saccharomyces cerevisiae (Data EntryID:97) |
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| Model type | ordinary differential equations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Category | Metabolism | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of reactions | 33 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of species | 29 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of regulators | not specified | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of parameters | 203 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of compartments | 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dilution rate (h-1) | — | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Model file(s) and history |
LATEST smallbone18.xml
(2018-07-16 19:34:20 UTC
by Administrator KiMoSysFirst name: AdministratorAffiliation: INESC-ID/IST Homepage: http://kdbio.inesc-id.pt/kimosys Interests: mathematical modeling, accessible data, use of data ) Preview Preview file smallbone18.xml<?xml version='1.0' encoding='UTF-8' standalone='no'?>
<sbml level='3' version='1' xmlns='http://www.sbml.org/sbml/level3/version1/core'>
<model id='smallbone18' name='smallbone18'>
<listOfCompartments>
<compartment constant='true' id='default_compartment' metaid='metaid_0' sboTerm='SBO:0000410' size='1' spatialDimensions='3'/>
</listOfCompartments>
<listOfSpecies>
<species boundaryCondition='true' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='ACE' initialConcentration='223.000253398294' metaid='metaid_1'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='ADP' initialConcentration='1.29' metaid='metaid_2'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='AMP' initialConcentration='0.44' metaid='metaid_3'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='ATP' initialConcentration='4.29' metaid='metaid_4'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='AcAld' initialConcentration='0.178140579850657' metaid='metaid_5'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='BPG' initialConcentration='0.000736873499865602' metaid='metaid_6'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='DHAP' initialConcentration='1.1613768527467' metaid='metaid_7'/>
<species boundaryCondition='true' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='EtOH' initialConcentration='221.890311417536' metaid='metaid_8'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='F16bP' initialConcentration='4.58321859006931' metaid='metaid_9'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='F6P' initialConcentration='0.235441221891221' metaid='metaid_10'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='G1P' initialConcentration='0.539248506344921' metaid='metaid_11'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='G3P' initialConcentration='0.274002929191284' metaid='metaid_12'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='G6P' initialConcentration='0.772483203645216' metaid='metaid_13'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='GAP' initialConcentration='0.315891028770503' metaid='metaid_14'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='GLC' initialConcentration='6.28000179338242' metaid='metaid_15'/>
<species boundaryCondition='true' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='GLCx' initialConcentration='74' metaid='metaid_16'/>
<species boundaryCondition='true' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='GLY' initialConcentration='0.15' metaid='metaid_17'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='NAD' initialConcentration='1.50329030201531' metaid='metaid_18'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='NADH' initialConcentration='0.0867096979846952' metaid='metaid_19'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='P2G' initialConcentration='0.0677379081099344' metaid='metaid_20'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='P3G' initialConcentration='0.469825011134444' metaid='metaid_21'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='PEP' initialConcentration='0.610005413358042' metaid='metaid_22'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='PYR' initialConcentration='2.10847140717419' metaid='metaid_23'/>
<species boundaryCondition='true' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='SUC' initialConcentration='0' metaid='metaid_24'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='T6P' initialConcentration='0.02' metaid='metaid_25'/>
<species boundaryCondition='true' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='TRH' initialConcentration='0.0153878853696526' metaid='metaid_26'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='UDG' initialConcentration='0.467246194874247' metaid='metaid_27'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='UDP' initialConcentration='0.2815' metaid='metaid_28'/>
<species boundaryCondition='false' compartment='default_compartment' constant='false' hasOnlySubstanceUnits='false' id='UTP' initialConcentration='0.6491' metaid='metaid_29'/>
</listOfSpecies>
<listOfParameters>
<parameter constant='false' id='ADH1' metaid='metaid_30' value='0.163908510928009'/>
<parameter constant='false' id='ADH5' metaid='metaid_31' value='0.00424998422487687'/>
<parameter constant='false' id='ADHADH1Kacald' metaid='metaid_32' value='0.4622'/>
<parameter constant='false' id='ADHADH1Ketoh' metaid='metaid_33' value='17'/>
<parameter constant='false' id='ADHADH1Kiacald' metaid='metaid_34' value='1.1'/>
<parameter constant='false' id='ADHADH1Kietoh' metaid='metaid_35' value='90'/>
<parameter constant='false' id='ADHADH1Kinad' metaid='metaid_36' value='0.92'/>
<parameter constant='false' id='ADHADH1Kinadh' metaid='metaid_37' value='0.031'/>
<parameter constant='false' id='ADHADH1Knad' metaid='metaid_38' value='0.17'/>
<parameter constant='false' id='ADHADH1Knadh' metaid='metaid_39' value='0.11'/>
<parameter constant='false' id='ADHADH1kcat' metaid='metaid_40' value='176'/>
<parameter constant='false' id='ADHADH5Kacald' metaid='metaid_41' value='1.11'/>
<parameter constant='false' id='ADHADH5Ketoh' metaid='metaid_42' value='17'/>
<parameter constant='false' id='ADHADH5Kiacald' metaid='metaid_43' value='1.1'/>
<parameter constant='false' id='ADHADH5Kietoh' metaid='metaid_44' value='90'/>
<parameter constant='false' id='ADHADH5Kinad' metaid='metaid_45' value='0.92'/>
<parameter constant='false' id='ADHADH5Kinadh' metaid='metaid_46' value='0.031'/>
<parameter constant='false' id='ADHADH5Knad' metaid='metaid_47' value='0.17'/>
<parameter constant='false' id='ADHADH5Knadh' metaid='metaid_48' value='0.11'/>
<parameter constant='false' id='ADHADH5kcat' metaid='metaid_49' value='0'/>
<parameter constant='false' id='AKKeq' metaid='metaid_50' value='0.45'/>
<parameter constant='false' id='AKk' metaid='metaid_51' value='0.75'/>
<parameter constant='false' id='ATPaseKatp' metaid='metaid_52' value='3'/>
<parameter constant='false' id='ATPaseVmax' metaid='metaid_53' value='6.16'/>
<parameter constant='false' id='CDC19' metaid='metaid_54' value='2.0483901071712'/>
<parameter constant='false' id='ENO1' metaid='metaid_55' value='0.686371954155832'/>
<parameter constant='false' id='ENO2' metaid='metaid_56' value='1.97444629317817'/>
<parameter constant='false' id='ENOENO1Kp2g' metaid='metaid_57' value='0.043'/>
<parameter constant='false' id='ENOENO1Kpep' metaid='metaid_58' value='0.5'/>
<parameter constant='false' id='ENOENO1kcat' metaid='metaid_59' value='7.6'/>
<parameter constant='false' id='ENOENO2Kp2g' metaid='metaid_60' value='0.104'/>
<parameter constant='false' id='ENOENO2Kpep' metaid='metaid_61' value='0.5'/>
<parameter constant='false' id='ENOENO2kcat' metaid='metaid_62' value='19.87'/>
<parameter constant='false' id='EXTERNAL' metaid='metaid_63' value='0'/>
<parameter constant='false' id='F26bP' metaid='metaid_64' value='0.003'/>
<parameter constant='false' id='FBA1' metaid='metaid_65' value='1.33839465704882'/>
<parameter constant='false' id='FBAKdhap' metaid='metaid_66' value='2'/>
<parameter constant='false' id='FBAKeq' metaid='metaid_67' value='0.069'/>
<parameter constant='false' id='FBAKf16bp' metaid='metaid_68' value='0.4507'/>
<parameter constant='false' id='FBAKgap' metaid='metaid_69' value='2.4'/>
<parameter constant='false' id='FBAKigap' metaid='metaid_70' value='10'/>
<parameter constant='false' id='FBAkcat' metaid='metaid_71' value='4.139'/>
<parameter constant='false' id='GLK1' metaid='metaid_72' value='0.0450869624419226'/>
<parameter constant='false' id='GPD1' metaid='metaid_73' value='0.00683511177089872'/>
<parameter constant='false' id='GPD2' metaid='metaid_74' value='0.000793405666424228'/>
<parameter constant='false' id='GPDKadp' metaid='metaid_75' value='2'/>
<parameter constant='false' id='GPDKatp' metaid='metaid_76' value='0.73'/>
<parameter constant='false' id='GPDKdhap' metaid='metaid_77' value='0.54'/>
<parameter constant='false' id='GPDKeq' metaid='metaid_78' value='10000'/>
<parameter constant='false' id='GPDKfbp' metaid='metaid_79' value='4.8'/>
<parameter constant='false' id='GPDKg3p' metaid='metaid_80' value='1.2'/>
<parameter constant='false' id='GPDKnad' metaid='metaid_81' value='0.93'/>
<parameter constant='false' id='GPDKnadh' metaid='metaid_82' value='0.023'/>
<parameter constant='false' id='GPDVmax' metaid='metaid_83' value='0.783333333333333'/>
<parameter constant='false' id='GPM1' metaid='metaid_84' value='0.73000029889707'/>
<parameter constant='false' id='GPMKeq' metaid='metaid_85' value='0.19'/>
<parameter constant='false' id='GPMKp2g' metaid='metaid_86' value='1.41'/>
<parameter constant='false' id='GPMKp3g' metaid='metaid_87' value='1.2'/>
<parameter constant='false' id='GPMkcat' metaid='metaid_88' value='400'/>
<parameter constant='false' id='GPPKg3p' metaid='metaid_89' value='3.5'/>
<parameter constant='false' id='GPPVmax' metaid='metaid_90' value='0.883333333333333'/>
<parameter constant='false' id='HOR2' metaid='metaid_91' value='0.0054734695639756'/>
<parameter constant='false' id='HXK1' metaid='metaid_92' value='0.0167807457149784'/>
<parameter constant='false' id='HXK2' metaid='metaid_93' value='0.0613313539705155'/>
<parameter constant='false' id='HXKGLK1Kadp' metaid='metaid_94' value='0.23'/>
<parameter constant='false' id='HXKGLK1Katp' metaid='metaid_95' value='0.865'/>
<parameter constant='false' id='HXKGLK1Kg6p' metaid='metaid_96' value='30'/>
<parameter constant='false' id='HXKGLK1Kglc' metaid='metaid_97' value='0.0106'/>
<parameter constant='false' id='HXKGLK1kcat' metaid='metaid_98' value='0.0721'/>
<parameter constant='false' id='HXKHXK1Kadp' metaid='metaid_99' value='0.23'/>
<parameter constant='false' id='HXKHXK1Katp' metaid='metaid_100' value='0.293'/>
<parameter constant='false' id='HXKHXK1Kg6p' metaid='metaid_101' value='30'/>
<parameter constant='false' id='HXKHXK1Kglc' metaid='metaid_102' value='0.15'/>
<parameter constant='false' id='HXKHXK1Kit6p' metaid='metaid_103' value='0.2'/>
<parameter constant='false' id='HXKHXK1kcat' metaid='metaid_104' value='10.2'/>
<parameter constant='false' id='HXKHXK2Kadp' metaid='metaid_105' value='0.23'/>
<parameter constant='false' id='HXKHXK2Katp' metaid='metaid_106' value='0.195'/>
<parameter constant='false' id='HXKHXK2Kg6p' metaid='metaid_107' value='30'/>
<parameter constant='false' id='HXKHXK2Kglc' metaid='metaid_108' value='0.2'/>
<parameter constant='false' id='HXKHXK2Kit6p' metaid='metaid_109' value='0.04'/>
<parameter constant='false' id='HXKHXK2kcat' metaid='metaid_110' value='63.1'/>
<parameter constant='false' id='HXTKglc' metaid='metaid_111' value='0.9'/>
<parameter constant='false' id='HXTKi' metaid='metaid_112' value='0.91'/>
<parameter constant='false' id='HXTVmax' metaid='metaid_113' value='3.35'/>
<parameter constant='false' id='KeqADH' metaid='metaid_114' value='14492.7536231884'/>
<parameter constant='false' id='KeqENO' metaid='metaid_115' value='6.7'/>
<parameter constant='false' id='KeqHXK' metaid='metaid_116' value='2000'/>
<parameter constant='false' id='KeqPYK' metaid='metaid_117' value='6500'/>
<parameter constant='false' id='KeqTDH' metaid='metaid_118' value='0.00533412710224736'/>
<parameter constant='false' id='NA' metaid='metaid_119' value='6.02214e+20'/>
<parameter constant='false' id='PDC1' metaid='metaid_120' value='1.06781077822834'/>
<parameter constant='false' id='PDC5' metaid='metaid_121' value='0.0123547443267676'/>
<parameter constant='false' id='PDC6' metaid='metaid_122' value='0.00654086421106118'/>
<parameter constant='false' id='PDCPDC1Kpyr' metaid='metaid_123' value='8.5'/>
<parameter constant='false' id='PDCPDC1kcat' metaid='metaid_124' value='12.14'/>
<parameter constant='false' id='PDCPDC5Kpyr' metaid='metaid_125' value='7.08'/>
<parameter constant='false' id='PDCPDC5kcat' metaid='metaid_126' value='10.32'/>
<parameter constant='false' id='PDCPDC6Kpyr' metaid='metaid_127' value='2.92'/>
<parameter constant='false' id='PDCPDC6kcat' metaid='metaid_128' value='9.21'/>
<parameter constant='false' id='PFK1' metaid='metaid_129' value='0.0467850299063124'/>
<parameter constant='false' id='PFK2' metaid='metaid_130' value='0.0390366215332091'/>
<parameter constant='false' id='PFKCamp' metaid='metaid_131' value='0.0845'/>
<parameter constant='false' id='PFKCatp' metaid='metaid_132' value='3'/>
<parameter constant='false' id='PFKCf16' metaid='metaid_133' value='0.397'/>
<parameter constant='false' id='PFKCf26' metaid='metaid_134' value='0.0174'/>
<parameter constant='false' id='PFKCiatp' metaid='metaid_135' value='100'/>
<parameter constant='false' id='PFKKadp' metaid='metaid_136' value='1'/>
<parameter constant='false' id='PFKKamp' metaid='metaid_137' value='0.0995'/>
<parameter constant='false' id='PFKKatp' metaid='metaid_138' value='0.71'/>
<parameter constant='false' id='PFKKeq' metaid='metaid_139' value='800'/>
<parameter constant='false' id='PFKKf16' metaid='metaid_140' value='0.111'/>
<parameter constant='false' id='PFKKf26' metaid='metaid_141' value='0.000682'/>
<parameter constant='false' id='PFKKf6p' metaid='metaid_142' value='0.1'/>
<parameter constant='false' id='PFKKiatp' metaid='metaid_143' value='0.65'/>
<parameter constant='false' id='PFKL0' metaid='metaid_144' value='0.66'/>
<parameter constant='false' id='PFKgR' metaid='metaid_145' value='5.12'/>
<parameter constant='false' id='PFKkcat' metaid='metaid_146' value='209.6'/>
<parameter constant='false' id='PGI1' metaid='metaid_147' value='0.1382907072901'/>
<parameter constant='false' id='PGIKeq' metaid='metaid_148' value='0.29'/>
<parameter constant='false' id='PGIKf6p' metaid='metaid_149' value='0.307'/>
<parameter constant='false' id='PGIKg6p' metaid='metaid_150' value='1.0257'/>
<parameter constant='false' id='PGIkcat' metaid='metaid_151' value='487.36'/>
<parameter constant='false' id='PGK1' metaid='metaid_152' value='0.257656912658955'/>
<parameter constant='false' id='PGKKadp' metaid='metaid_153' value='0.2'/>
<parameter constant='false' id='PGKKatp' metaid='metaid_154' value='1.99'/>
<parameter constant='false' id='PGKKbpg' metaid='metaid_155' value='0.003'/>
<parameter constant='false' id='PGKKeq' metaid='metaid_156' value='3200'/>
<parameter constant='false' id='PGKKp3g' metaid='metaid_157' value='4.58'/>
<parameter constant='false' id='PGKkcat' metaid='metaid_158' value='58.6'/>
<parameter constant='false' id='PGKnHadp' metaid='metaid_159' value='2'/>
<parameter constant='false' id='PGM1' metaid='metaid_160' value='0.00326229546307459'/>
<parameter constant='false' id='PGM2' metaid='metaid_161' value='0.00125868877176552'/>
<parameter constant='false' id='PGMKeq' metaid='metaid_162' value='0.1667'/>
<parameter constant='false' id='PGMKg1p' metaid='metaid_163' value='0.023'/>
<parameter constant='false' id='PGMKg6p' metaid='metaid_164' value='0.05'/>
<parameter constant='false' id='PGMVmax' metaid='metaid_165' value='0.12762'/>
<parameter constant='false' id='PYK2' metaid='metaid_166' value='0.00606993527217899'/>
<parameter constant='false' id='PYKCDC19Kadp' metaid='metaid_167' value='0.243'/>
<parameter constant='false' id='PYKCDC19Katp' metaid='metaid_168' value='1.5'/>
<parameter constant='false' id='PYKCDC19Kf16p' metaid='metaid_169' value='0.2'/>
<parameter constant='false' id='PYKCDC19Kiatp' metaid='metaid_170' value='9.3'/>
<parameter constant='false' id='PYKCDC19Kpep' metaid='metaid_171' value='0.281'/>
<parameter constant='false' id='PYKCDC19Kpyr' metaid='metaid_172' value='21'/>
<parameter constant='false' id='PYKCDC19L0' metaid='metaid_173' value='100'/>
<parameter constant='false' id='PYKCDC19kcat' metaid='metaid_174' value='20.146'/>
<parameter constant='false' id='PYKPYK2Kadp' metaid='metaid_175' value='0.3'/>
<parameter constant='false' id='PYKPYK2Katp' metaid='metaid_176' value='1.5'/>
<parameter constant='false' id='PYKPYK2Kf16p' metaid='metaid_177' value='0.2'/>
<parameter constant='false' id='PYKPYK2Kiatp' metaid='metaid_178' value='9.3'/>
<parameter constant='false' id='PYKPYK2Kpep' metaid='metaid_179' value='0.19'/>
<parameter constant='false' id='PYKPYK2Kpyr' metaid='metaid_180' value='21'/>
<parameter constant='false' id='PYKPYK2L0' metaid='metaid_181' value='100'/>
<parameter constant='false' id='PYKPYK2kcat' metaid='metaid_182' value='0'/>
<parameter constant='false' id='RHR2' metaid='metaid_183' value='0.0511804773718313'/>
<parameter constant='false' id='TDH1' metaid='metaid_184' value='0.350864642801396'/>
<parameter constant='false' id='TDH2' metaid='metaid_185' value='0'/>
<parameter constant='false' id='TDH3' metaid='metaid_186' value='4.20440474648547'/>
<parameter constant='false' id='TDHTDH1Kbpg' metaid='metaid_187' value='0.0098'/>
<parameter constant='false' id='TDHTDH1Kgap' metaid='metaid_188' value='0.495'/>
<parameter constant='false' id='TDHTDH1Knad' metaid='metaid_189' value='0.09'/>
<parameter constant='false' id='TDHTDH1Knadh' metaid='metaid_190' value='0.06'/>
<parameter constant='false' id='TDHTDH1kcat' metaid='metaid_191' value='19.12'/>
<parameter constant='false' id='TDHTDH2Kbpg' metaid='metaid_192' value='0.0098'/>
<parameter constant='false' id='TDHTDH2Kgap' metaid='metaid_193' value='0.77'/>
<parameter constant='false' id='TDHTDH2Knad' metaid='metaid_194' value='0.09'/>
<parameter constant='false' id='TDHTDH2Knadh' metaid='metaid_195' value='0.06'/>
<parameter constant='false' id='TDHTDH2kcat' metaid='metaid_196' value='8.633'/>
<parameter constant='false' id='TDHTDH3Kbpg' metaid='metaid_197' value='0.909'/>
<parameter constant='false' id='TDHTDH3Kgap' metaid='metaid_198' value='0.423'/>
<parameter constant='false' id='TDHTDH3Knad' metaid='metaid_199' value='0.09'/>
<parameter constant='false' id='TDHTDH3Knadh' metaid='metaid_200' value='0.06'/>
<parameter constant='false' id='TDHTDH3kcat' metaid='metaid_201' value='18.162'/>
<parameter constant='false' id='TPI1' metaid='metaid_202' value='0.294357819645508'/>
<parameter constant='false' id='TPIKdhap' metaid='metaid_203' value='6.454'/>
<parameter constant='false' id='TPIKeq' metaid='metaid_204' value='0.045'/>
<parameter constant='false' id='TPIKgap' metaid='metaid_205' value='5.25'/>
<parameter constant='false' id='TPIKigap' metaid='metaid_206' value='35.1'/>
<parameter constant='false' id='TPIkcat' metaid='metaid_207' value='564.38'/>
<parameter constant='false' id='TPPKt6p' metaid='metaid_208' value='0.5'/>
<parameter constant='false' id='TPPVmax' metaid='metaid_209' value='2.33999999999999'/>
<parameter constant='false' id='TPS1' metaid='metaid_210' value='0.00339248174237065'/>
<parameter constant='false' id='TPS2' metaid='metaid_211' value='0.00265985181347494'/>
<parameter constant='false' id='TPSKg6p' metaid='metaid_212' value='3.8'/>
<parameter constant='false' id='TPSKudg' metaid='metaid_213' value='0.886'/>
<parameter constant='false' id='TPSVmax' metaid='metaid_214' value='0.49356'/>
<parameter constant='false' id='UGP1' metaid='metaid_215' value='0.00620211419860714'/>
<parameter constant='false' id='UGPKg1p' metaid='metaid_216' value='0.32'/>
<parameter constant='false' id='UGPKiudg' metaid='metaid_217' value='0.0035'/>
<parameter constant='false' id='UGPKiutp' metaid='metaid_218' value='0.11'/>
<parameter constant='false' id='UGPKutp' metaid='metaid_219' value='0.11'/>
<parameter constant='false' id='UGPVmax' metaid='metaid_220' value='13.2552'/>
<parameter constant='false' id='acetatebranchk' metaid='metaid_221' value='0.00554339592436782'/>
<parameter constant='false' id='cell' metaid='metaid_222' value='1'/>
<parameter constant='false' id='energycharge' metaid='metaid_223' value='0'/>
<parameter constant='false' id='extracellular' metaid='metaid_224' value='1'/>
<parameter constant='false' id='fitconc' metaid='metaid_225' value='0'/>
<parameter constant='false' id='succinatebranchk' metaid='metaid_226' value='0'/>
<parameter constant='false' id='sumAXP' metaid='metaid_227' value='6.02'/>
<parameter constant='false' id='sumNAD' metaid='metaid_228' value='1.59'/>
<parameter constant='false' id='sumPXG' metaid='metaid_229' value='0'/>
<parameter constant='false' id='sumUXP' metaid='metaid_230' value='1.39784619487425'/>
<parameter constant='false' id='udptoutpk' metaid='metaid_231' value='0.0745258294103764'/>
<parameter constant='false' id='volume' metaid='metaid_232' value='5e-15'/>
</listOfParameters>
<listOfRules>
<assignmentRule metaid='metaid_233' variable='fitconc'>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<root/>
<degree>
<cn type='integer'> 2 </cn>
</degree>
<apply>
<plus/>
<apply>
<power/>
<apply>
<minus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> NA </ci>
<ci> sumPXG </ci>
<ci> volume </ci>
</apply>
<cn type='integer'> 1618640 </cn>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<power/>
<apply>
<minus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> NA </ci>
<ci> volume </ci>
<ci> DHAP </ci>
</apply>
<cn type='integer'> 3496987 </cn>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<power/>
<apply>
<minus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> NA </ci>
<ci> volume </ci>
<ci> F16bP </ci>
</apply>
<cn type='integer'> 13800392 </cn>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<power/>
<apply>
<minus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> NA </ci>
<ci> volume </ci>
<ci> F6P </ci>
</apply>
<cn type='integer'> 708930 </cn>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<power/>
<apply>
<minus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> NA </ci>
<ci> volume </ci>
<ci> G6P </ci>
</apply>
<cn type='integer'> 2326001 </cn>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<power/>
<apply>
<minus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> NA </ci>
<ci> volume </ci>
<ci> GAP </ci>
</apply>
<cn type='integer'> 951170 </cn>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<power/>
<apply>
<minus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> NA </ci>
<ci> volume </ci>
<ci> GLC </ci>
</apply>
<cn type='integer'> 18909525 </cn>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<power/>
<apply>
<minus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> NA </ci>
<ci> volume </ci>
<ci> PEP </ci>
</apply>
<cn type='integer'> 1836769 </cn>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<power/>
<apply>
<minus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> NA </ci>
<ci> volume </ci>
<ci> PYR </ci>
</apply>
<cn type='integer'> 6348755 </cn>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
</apply>
</apply>
<cn type='integer'> 3 </cn>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid='metaid_234' variable='sumPXG'>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<plus/>
<ci> P2G </ci>
<ci> P3G </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid='metaid_235' variable='energycharge'>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<divide/>
<ci> ADP </ci>
<cn type='integer'> 2 </cn>
</apply>
<ci> ATP </ci>
</apply>
<ci> sumAXP </ci>
</apply>
</math>
</assignmentRule>
</listOfRules>
<listOfReactions>
<reaction fast='false' id='ADHADH1' metaid='metaid_240' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_236' species='AcAld' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_237' species='NADH' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_238' species='NAD' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_239' species='EtOH' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> ADH1 </ci>
<ci> ADHADH1kcat </ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> EtOH </ci>
<ci> NAD </ci>
</apply>
<apply>
<times/>
<ci> ADHADH1Kacald </ci>
<ci> ADHADH1Kinadh </ci>
<ci> KeqADH </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> AcAld </ci>
<ci> NADH </ci>
</apply>
<apply>
<times/>
<ci> ADHADH1Kacald </ci>
<ci> ADHADH1Kinadh </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> ADHADH1Knad </ci>
<ci> EtOH </ci>
</apply>
<apply>
<times/>
<ci> ADHADH1Ketoh </ci>
<ci> ADHADH1Kinad </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ADHADH1Knadh </ci>
<ci> AcAld </ci>
</apply>
<apply>
<times/>
<ci> ADHADH1Kacald </ci>
<ci> ADHADH1Kinadh </ci>
</apply>
</apply>
<apply>
<divide/>
<ci> NAD </ci>
<ci> ADHADH1Kinad </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> EtOH </ci>
<ci> NAD </ci>
</apply>
<apply>
<times/>
<ci> ADHADH1Ketoh </ci>
<ci> ADHADH1Kinad </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ADHADH1Knadh </ci>
<ci> AcAld </ci>
<ci> NAD </ci>
</apply>
<apply>
<times/>
<ci> ADHADH1Kacald </ci>
<ci> ADHADH1Kinad </ci>
<ci> ADHADH1Kinadh </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> EtOH </ci>
<ci> AcAld </ci>
<ci> NAD </ci>
</apply>
<apply>
<times/>
<ci> ADHADH1Ketoh </ci>
<ci> ADHADH1Kiacald </ci>
<ci> ADHADH1Kinad </ci>
</apply>
</apply>
<apply>
<divide/>
<ci> NADH </ci>
<ci> ADHADH1Kinadh </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ADHADH1Knad </ci>
<ci> EtOH </ci>
<ci> NADH </ci>
</apply>
<apply>
<times/>
<ci> ADHADH1Ketoh </ci>
<ci> ADHADH1Kinad </ci>
<ci> ADHADH1Kinadh </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> AcAld </ci>
<ci> NADH </ci>
</apply>
<apply>
<times/>
<ci> ADHADH1Kacald </ci>
<ci> ADHADH1Kinadh </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> EtOH </ci>
<ci> AcAld </ci>
<ci> NADH </ci>
</apply>
<apply>
<times/>
<ci> ADHADH1Kacald </ci>
<ci> ADHADH1Kietoh </ci>
<ci> ADHADH1Kinadh </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='ADHADH5' metaid='metaid_245' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_241' species='AcAld' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_242' species='NADH' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_243' species='NAD' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_244' species='EtOH' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> ADH5 </ci>
<ci> ADHADH5kcat </ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> EtOH </ci>
<ci> NAD </ci>
</apply>
<apply>
<times/>
<ci> ADHADH5Kacald </ci>
<ci> ADHADH5Kinadh </ci>
<ci> KeqADH </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> AcAld </ci>
<ci> NADH </ci>
</apply>
<apply>
<times/>
<ci> ADHADH5Kacald </ci>
<ci> ADHADH5Kinadh </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> ADHADH5Knad </ci>
<ci> EtOH </ci>
</apply>
<apply>
<times/>
<ci> ADHADH5Ketoh </ci>
<ci> ADHADH5Kinad </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ADHADH5Knadh </ci>
<ci> AcAld </ci>
</apply>
<apply>
<times/>
<ci> ADHADH5Kacald </ci>
<ci> ADHADH5Kinadh </ci>
</apply>
</apply>
<apply>
<divide/>
<ci> NAD </ci>
<ci> ADHADH5Kinad </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> EtOH </ci>
<ci> NAD </ci>
</apply>
<apply>
<times/>
<ci> ADHADH5Ketoh </ci>
<ci> ADHADH5Kinad </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ADHADH5Knadh </ci>
<ci> AcAld </ci>
<ci> NAD </ci>
</apply>
<apply>
<times/>
<ci> ADHADH5Kacald </ci>
<ci> ADHADH5Kinad </ci>
<ci> ADHADH5Kinadh </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> EtOH </ci>
<ci> AcAld </ci>
<ci> NAD </ci>
</apply>
<apply>
<times/>
<ci> ADHADH5Ketoh </ci>
<ci> ADHADH5Kiacald </ci>
<ci> ADHADH5Kinad </ci>
</apply>
</apply>
<apply>
<divide/>
<ci> NADH </ci>
<ci> ADHADH5Kinadh </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ADHADH5Knad </ci>
<ci> EtOH </ci>
<ci> NADH </ci>
</apply>
<apply>
<times/>
<ci> ADHADH5Ketoh </ci>
<ci> ADHADH5Kinad </ci>
<ci> ADHADH5Kinadh </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> AcAld </ci>
<ci> NADH </ci>
</apply>
<apply>
<times/>
<ci> ADHADH5Kacald </ci>
<ci> ADHADH5Kinadh </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> EtOH </ci>
<ci> AcAld </ci>
<ci> NADH </ci>
</apply>
<apply>
<times/>
<ci> ADHADH5Kacald </ci>
<ci> ADHADH5Kietoh </ci>
<ci> ADHADH5Kinadh </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='AK' metaid='metaid_249' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_246' species='ADP' stoichiometry='2'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_247' species='AMP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_248' species='ATP' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<times/>
<ci> AKk </ci>
<apply>
<minus/>
<apply>
<power/>
<ci> ADP </ci>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> AMP </ci>
<ci> ATP </ci>
</apply>
<ci> AKKeq </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='ATPase' metaid='metaid_252' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_250' species='ATP' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_251' species='ADP' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> ATPaseVmax </ci>
<ci> ATP </ci>
</apply>
<apply>
<times/>
<ci> ATPaseKatp </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> ATP </ci>
<ci> ATPaseKatp </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='ENOENO1' metaid='metaid_255' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_253' species='P2G' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_254' species='PEP' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> ENO1 </ci>
<ci> ENOENO1kcat </ci>
<apply>
<minus/>
<apply>
<divide/>
<ci> P2G </ci>
<ci> ENOENO1Kp2g </ci>
</apply>
<apply>
<divide/>
<ci> PEP </ci>
<apply>
<times/>
<ci> ENOENO1Kp2g </ci>
<ci> KeqENO </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> P2G </ci>
<ci> ENOENO1Kp2g </ci>
</apply>
<apply>
<divide/>
<ci> PEP </ci>
<ci> ENOENO1Kpep </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='ENOENO2' metaid='metaid_258' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_256' species='P2G' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_257' species='PEP' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> ENO2 </ci>
<ci> ENOENO2kcat </ci>
<apply>
<minus/>
<apply>
<divide/>
<ci> P2G </ci>
<ci> ENOENO2Kp2g </ci>
</apply>
<apply>
<divide/>
<ci> PEP </ci>
<apply>
<times/>
<ci> ENOENO2Kp2g </ci>
<ci> KeqENO </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> P2G </ci>
<ci> ENOENO2Kp2g </ci>
</apply>
<apply>
<divide/>
<ci> PEP </ci>
<ci> ENOENO2Kpep </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='FBA' metaid='metaid_262' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_259' species='F16bP' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_260' species='DHAP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_261' species='GAP' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> FBA1 </ci>
<ci> FBAkcat </ci>
<apply>
<minus/>
<apply>
<divide/>
<ci> F16bP </ci>
<ci> FBAKf16bp </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> DHAP </ci>
<ci> GAP </ci>
</apply>
<apply>
<times/>
<ci> FBAKeq </ci>
<ci> FBAKf16bp </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> DHAP </ci>
<ci> FBAKdhap </ci>
</apply>
<apply>
<divide/>
<ci> F16bP </ci>
<ci> FBAKf16bp </ci>
</apply>
<apply>
<divide/>
<ci> GAP </ci>
<ci> FBAKgap </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> DHAP </ci>
<ci> GAP </ci>
</apply>
<apply>
<times/>
<ci> FBAKdhap </ci>
<ci> FBAKgap </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> F16bP </ci>
<ci> GAP </ci>
</apply>
<apply>
<times/>
<ci> FBAKf16bp </ci>
<ci> FBAKigap </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='GPD' metaid='metaid_270' name='GPD' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_263' species='DHAP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_264' species='NADH' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_265' species='G3P' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_266' species='NAD' stoichiometry='1'/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid='metaid_267' species='ADP'/>
<modifierSpeciesReference metaid='metaid_268' species='ATP'/>
<modifierSpeciesReference metaid='metaid_269' species='F16bP'/>
</listOfModifiers>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> GPDVmax </ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> G3P </ci>
<ci> NAD </ci>
</apply>
<ci> GPDKeq </ci>
</apply>
</apply>
<apply>
<times/>
<ci> DHAP </ci>
<ci> NADH </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> GPDKdhap </ci>
<ci> GPDKnadh </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> ADP </ci>
<ci> GPDKadp </ci>
</apply>
<apply>
<divide/>
<ci> ATP </ci>
<ci> GPDKatp </ci>
</apply>
<apply>
<divide/>
<ci> F16bP </ci>
<ci> GPDKfbp </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> DHAP </ci>
<ci> GPDKdhap </ci>
</apply>
<apply>
<divide/>
<ci> G3P </ci>
<ci> GPDKg3p </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> NAD </ci>
<ci> GPDKnad </ci>
</apply>
<apply>
<divide/>
<ci> NADH </ci>
<ci> GPDKnadh </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='GPM' metaid='metaid_273' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_271' species='P3G' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_272' species='P2G' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> GPM1 </ci>
<ci> GPMkcat </ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<ci> P2G </ci>
<apply>
<times/>
<ci> GPMKeq </ci>
<ci> GPMKp3g </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> P3G </ci>
<ci> GPMKp3g </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> P2G </ci>
<ci> GPMKp2g </ci>
</apply>
<apply>
<divide/>
<ci> P3G </ci>
<ci> GPMKp3g </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='GPP' metaid='metaid_276' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_274' species='G3P' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_275' species='GLY' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> GPPVmax </ci>
<ci> G3P </ci>
</apply>
<apply>
<times/>
<ci> GPPKg3p </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> G3P </ci>
<ci> GPPKg3p </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='HXKGLK1' metaid='metaid_281' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_277' species='ATP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_278' species='GLC' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_279' species='ADP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_280' species='G6P' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> GLK1 </ci>
<ci> HXKGLK1kcat </ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> ADP </ci>
<ci> G6P </ci>
</apply>
<apply>
<times/>
<ci> HXKGLK1Katp </ci>
<ci> HXKGLK1Kglc </ci>
<ci> KeqHXK </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ATP </ci>
<ci> GLC </ci>
</apply>
<apply>
<times/>
<ci> HXKGLK1Katp </ci>
<ci> HXKGLK1Kglc </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> ADP </ci>
<ci> HXKGLK1Kadp </ci>
</apply>
<apply>
<divide/>
<ci> ATP </ci>
<ci> HXKGLK1Katp </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> G6P </ci>
<ci> HXKGLK1Kg6p </ci>
</apply>
<apply>
<divide/>
<ci> GLC </ci>
<ci> HXKGLK1Kglc </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='HXKHXK1' metaid='metaid_287' name='HXKHXK1' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_282' species='ATP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_283' species='GLC' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_284' species='ADP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_285' species='G6P' stoichiometry='1'/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid='metaid_286' species='T6P'/>
</listOfModifiers>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> HXK1 </ci>
<ci> HXKHXK1kcat </ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> ADP </ci>
<ci> G6P </ci>
</apply>
<apply>
<times/>
<ci> HXKHXK1Katp </ci>
<ci> HXKHXK1Kglc </ci>
<ci> KeqHXK </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ATP </ci>
<ci> GLC </ci>
</apply>
<apply>
<times/>
<ci> HXKHXK1Katp </ci>
<ci> HXKHXK1Kglc </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> ADP </ci>
<ci> HXKHXK1Kadp </ci>
</apply>
<apply>
<divide/>
<ci> ATP </ci>
<ci> HXKHXK1Katp </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> G6P </ci>
<ci> HXKHXK1Kg6p </ci>
</apply>
<apply>
<divide/>
<ci> GLC </ci>
<ci> HXKHXK1Kglc </ci>
</apply>
<apply>
<divide/>
<ci> T6P </ci>
<ci> HXKHXK1Kit6p </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='HXKHXK2' metaid='metaid_293' name='HXKHXK2' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_288' species='ATP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_289' species='GLC' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_290' species='ADP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_291' species='G6P' stoichiometry='1'/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid='metaid_292' species='T6P'/>
</listOfModifiers>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> HXK2 </ci>
<ci> HXKHXK2kcat </ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> ADP </ci>
<ci> G6P </ci>
</apply>
<apply>
<times/>
<ci> HXKHXK2Katp </ci>
<ci> HXKHXK2Kglc </ci>
<ci> KeqHXK </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ATP </ci>
<ci> GLC </ci>
</apply>
<apply>
<times/>
<ci> HXKHXK2Katp </ci>
<ci> HXKHXK2Kglc </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> ADP </ci>
<ci> HXKHXK2Kadp </ci>
</apply>
<apply>
<divide/>
<ci> ATP </ci>
<ci> HXKHXK2Katp </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> G6P </ci>
<ci> HXKHXK2Kg6p </ci>
</apply>
<apply>
<divide/>
<ci> GLC </ci>
<ci> HXKHXK2Kglc </ci>
</apply>
<apply>
<divide/>
<ci> T6P </ci>
<ci> HXKHXK2Kit6p </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='HXT' metaid='metaid_296' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_294' species='GLCx' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_295' species='GLC' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> HXTVmax </ci>
<apply>
<minus/>
<ci> GLCx </ci>
<ci> GLC </ci>
</apply>
</apply>
<apply>
<times/>
<ci> HXTKglc </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> GLCx </ci>
<ci> HXTKglc </ci>
</apply>
<apply>
<divide/>
<ci> GLC </ci>
<ci> HXTKglc </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> GLCx </ci>
<ci> HXTKi </ci>
<ci> GLC </ci>
</apply>
<apply>
<power/>
<ci> HXTKglc </ci>
<cn type='integer'> 2 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='PDCPDC1' metaid='metaid_299' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_297' species='PYR' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_298' species='AcAld' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> PDC1 </ci>
<ci> PDCPDC1kcat </ci>
<ci> PYR </ci>
</apply>
<apply>
<times/>
<ci> PDCPDC1Kpyr </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> PYR </ci>
<ci> PDCPDC1Kpyr </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='PDCPDC5' metaid='metaid_302' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_300' species='PYR' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_301' species='AcAld' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> PDC5 </ci>
<ci> PDCPDC5kcat </ci>
<ci> PYR </ci>
</apply>
<apply>
<times/>
<ci> PDCPDC5Kpyr </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> PYR </ci>
<ci> PDCPDC5Kpyr </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='PDCPDC6' metaid='metaid_305' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_303' species='PYR' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_304' species='AcAld' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> PDC6 </ci>
<ci> PDCPDC6kcat </ci>
<ci> PYR </ci>
</apply>
<apply>
<times/>
<ci> PDCPDC6Kpyr </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> PYR </ci>
<ci> PDCPDC6Kpyr </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='PFK' metaid='metaid_311' name='PFK' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_306' species='ATP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_307' species='F6P' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_308' species='ADP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_309' species='F16bP' stoichiometry='1'/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid='metaid_310' species='AMP'/>
</listOfModifiers>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> PFKgR </ci>
<ci> PFKkcat </ci>
<apply>
<minus/>
<apply>
<plus/>
<ci> PFK1 </ci>
<ci> PFK2 </ci>
</apply>
<apply>
<abs/>
<apply>
<minus/>
<ci> PFK1 </ci>
<ci> PFK2 </ci>
</apply>
</apply>
</apply>
<ci> ATP </ci>
<apply>
<minus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> ADP </ci>
<ci> F16bP </ci>
</apply>
<apply>
<times/>
<ci> PFKKeq </ci>
<ci> ATP </ci>
<ci> F6P </ci>
</apply>
</apply>
</apply>
<ci> F6P </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> ADP </ci>
<ci> PFKKadp </ci>
</apply>
<apply>
<divide/>
<ci> ATP </ci>
<ci> PFKKatp </ci>
</apply>
<apply>
<divide/>
<ci> F16bP </ci>
<ci> PFKKf16 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> PFKgR </ci>
<ci> ADP </ci>
<ci> F16bP </ci>
</apply>
<apply>
<times/>
<ci> PFKKadp </ci>
<ci> PFKKf16 </ci>
</apply>
</apply>
<apply>
<divide/>
<ci> F6P </ci>
<ci> PFKKf6p </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> PFKgR </ci>
<ci> ATP </ci>
<ci> F6P </ci>
</apply>
<apply>
<times/>
<ci> PFKKatp </ci>
<ci> PFKKf6p </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn type='integer'> 2 </cn>
<ci> PFKKatp </ci>
<ci> PFKKf6p </ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> PFKL0 </ci>
<apply>
<power/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> PFKCamp </ci>
<ci> AMP </ci>
</apply>
<ci> PFKKamp </ci>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> PFKCatp </ci>
<ci> ATP </ci>
</apply>
<ci> PFKKatp </ci>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> PFKCiatp </ci>
<ci> ATP </ci>
</apply>
<ci> PFKKiatp </ci>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> F26bP </ci>
<ci> PFKCf26 </ci>
</apply>
<ci> PFKKf26 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> PFKCf16 </ci>
<ci> F16bP </ci>
</apply>
<ci> PFKKf16 </ci>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> AMP </ci>
<ci> PFKKamp </ci>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> ATP </ci>
<ci> PFKKiatp </ci>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> F26bP </ci>
<ci> PFKKf26 </ci>
</apply>
<apply>
<divide/>
<ci> F16bP </ci>
<ci> PFKKf16 </ci>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> ADP </ci>
<ci> PFKKadp </ci>
</apply>
<apply>
<divide/>
<ci> ATP </ci>
<ci> PFKKatp </ci>
</apply>
<apply>
<divide/>
<ci> F16bP </ci>
<ci> PFKKf16 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> PFKgR </ci>
<ci> ADP </ci>
<ci> F16bP </ci>
</apply>
<apply>
<times/>
<ci> PFKKadp </ci>
<ci> PFKKf16 </ci>
</apply>
</apply>
<apply>
<divide/>
<ci> F6P </ci>
<ci> PFKKf6p </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> PFKgR </ci>
<ci> ATP </ci>
<ci> F6P </ci>
</apply>
<apply>
<times/>
<ci> PFKKatp </ci>
<ci> PFKKf6p </ci>
</apply>
</apply>
</apply>
<cn type='integer'> 2 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='PGI' metaid='metaid_314' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_312' species='G6P' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_313' species='F6P' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> PGI1 </ci>
<ci> PGIkcat </ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<ci> F6P </ci>
<apply>
<times/>
<ci> PGIKeq </ci>
<ci> PGIKg6p </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> G6P </ci>
<ci> PGIKg6p </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> F6P </ci>
<ci> PGIKf6p </ci>
</apply>
<apply>
<divide/>
<ci> G6P </ci>
<ci> PGIKg6p </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='PGK' metaid='metaid_319' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_315' species='ADP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_316' species='BPG' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_317' species='ATP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_318' species='P3G' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> PGK1 </ci>
<ci> PGKkcat </ci>
<apply>
<power/>
<apply>
<divide/>
<ci> ADP </ci>
<ci> PGKKadp </ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<cn type='integer'> 1 </cn>
</apply>
<ci> PGKnHadp </ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> ADP </ci>
<ci> BPG </ci>
</apply>
<apply>
<times/>
<ci> PGKKadp </ci>
<ci> PGKKbpg </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ATP </ci>
<ci> P3G </ci>
</apply>
<apply>
<times/>
<ci> PGKKadp </ci>
<ci> PGKKbpg </ci>
<ci> PGKKeq </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<power/>
<apply>
<divide/>
<ci> ADP </ci>
<ci> PGKKadp </ci>
</apply>
<ci> PGKnHadp </ci>
</apply>
<apply>
<divide/>
<ci> ATP </ci>
<ci> PGKKatp </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> BPG </ci>
<ci> PGKKbpg </ci>
</apply>
<apply>
<divide/>
<ci> P3G </ci>
<ci> PGKKp3g </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='PGM' metaid='metaid_322' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_320' species='G6P' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_321' species='G1P' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> PGMVmax </ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<ci> G1P </ci>
<apply>
<times/>
<ci> PGMKeq </ci>
<ci> PGMKg6p </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> G6P </ci>
<ci> PGMKg6p </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> G1P </ci>
<ci> PGMKg1p </ci>
</apply>
<apply>
<divide/>
<ci> G6P </ci>
<ci> PGMKg6p </ci>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='PYKCDC19' metaid='metaid_328' name='PYKCDC19' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_323' species='ADP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_324' species='PEP' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_325' species='ATP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_326' species='PYR' stoichiometry='1'/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid='metaid_327' species='F16bP'/>
</listOfModifiers>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> CDC19 </ci>
<ci> PYKCDC19kcat </ci>
<apply>
<minus/>
<apply>
<times/>
<ci> ADP </ci>
<ci> PEP </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ATP </ci>
<ci> PYR </ci>
</apply>
<ci> KeqPYK </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> PYKCDC19Kadp </ci>
<ci> PYKCDC19Kpep </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> ADP </ci>
<ci> PYKCDC19Kadp </ci>
</apply>
<apply>
<divide/>
<ci> ATP </ci>
<ci> PYKCDC19Katp </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> PYKCDC19L0 </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> ATP </ci>
<ci> PYKCDC19Kiatp </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> F16bP </ci>
<ci> PYKCDC19Kf16p </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> PEP </ci>
<ci> PYKCDC19Kpep </ci>
</apply>
<apply>
<divide/>
<ci> PYR </ci>
<ci> PYKCDC19Kpyr </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='PYKPYK2' metaid='metaid_334' name='PYKPYK2' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_329' species='ADP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_330' species='PEP' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_331' species='ATP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_332' species='PYR' stoichiometry='1'/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid='metaid_333' species='F16bP'/>
</listOfModifiers>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> PYK2 </ci>
<ci> PYKPYK2kcat </ci>
<apply>
<minus/>
<apply>
<times/>
<ci> ADP </ci>
<ci> PEP </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ATP </ci>
<ci> PYR </ci>
</apply>
<ci> KeqPYK </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> PYKPYK2Kadp </ci>
<ci> PYKPYK2Kpep </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> ADP </ci>
<ci> PYKPYK2Kadp </ci>
</apply>
<apply>
<divide/>
<ci> ATP </ci>
<ci> PYKPYK2Katp </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> PYKPYK2L0 </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> ATP </ci>
<ci> PYKPYK2Kiatp </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> F16bP </ci>
<ci> PYKPYK2Kf16p </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> PEP </ci>
<ci> PYKPYK2Kpep </ci>
</apply>
<apply>
<divide/>
<ci> PYR </ci>
<ci> PYKPYK2Kpyr </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='TDHTDH1' metaid='metaid_339' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_335' species='GAP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_336' species='NAD' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_337' species='BPG' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_338' species='NADH' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> TDH1 </ci>
<ci> TDHTDH1kcat </ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> GAP </ci>
<ci> NAD </ci>
</apply>
<apply>
<times/>
<ci> TDHTDH1Kgap </ci>
<ci> TDHTDH1Knad </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> BPG </ci>
<ci> NADH </ci>
</apply>
<apply>
<times/>
<ci> KeqTDH </ci>
<ci> TDHTDH1Kgap </ci>
<ci> TDHTDH1Knad </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> BPG </ci>
<ci> TDHTDH1Kbpg </ci>
</apply>
<apply>
<divide/>
<ci> GAP </ci>
<ci> TDHTDH1Kgap </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> NAD </ci>
<ci> TDHTDH1Knad </ci>
</apply>
<apply>
<divide/>
<ci> NADH </ci>
<ci> TDHTDH1Knadh </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='TDHTDH2' metaid='metaid_344' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_340' species='GAP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_341' species='NAD' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_342' species='BPG' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_343' species='NADH' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> TDH2 </ci>
<ci> TDHTDH2kcat </ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> GAP </ci>
<ci> NAD </ci>
</apply>
<apply>
<times/>
<ci> TDHTDH2Kgap </ci>
<ci> TDHTDH2Knad </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> BPG </ci>
<ci> NADH </ci>
</apply>
<apply>
<times/>
<ci> KeqTDH </ci>
<ci> TDHTDH2Kgap </ci>
<ci> TDHTDH2Knad </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> BPG </ci>
<ci> TDHTDH2Kbpg </ci>
</apply>
<apply>
<divide/>
<ci> GAP </ci>
<ci> TDHTDH2Kgap </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> NAD </ci>
<ci> TDHTDH2Knad </ci>
</apply>
<apply>
<divide/>
<ci> NADH </ci>
<ci> TDHTDH2Knadh </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='TDHTDH3' metaid='metaid_349' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_345' species='GAP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_346' species='NAD' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_347' species='BPG' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_348' species='NADH' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> TDH3 </ci>
<ci> TDHTDH3kcat </ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> GAP </ci>
<ci> NAD </ci>
</apply>
<apply>
<times/>
<ci> TDHTDH3Kgap </ci>
<ci> TDHTDH3Knad </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> BPG </ci>
<ci> NADH </ci>
</apply>
<apply>
<times/>
<ci> KeqTDH </ci>
<ci> TDHTDH3Kgap </ci>
<ci> TDHTDH3Knad </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> BPG </ci>
<ci> TDHTDH3Kbpg </ci>
</apply>
<apply>
<divide/>
<ci> GAP </ci>
<ci> TDHTDH3Kgap </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> NAD </ci>
<ci> TDHTDH3Knad </ci>
</apply>
<apply>
<divide/>
<ci> NADH </ci>
<ci> TDHTDH3Knadh </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='TPI' metaid='metaid_352' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_350' species='DHAP' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_351' species='GAP' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> TPI1 </ci>
<ci> TPIkcat </ci>
<apply>
<minus/>
<ci> DHAP </ci>
<apply>
<divide/>
<ci> GAP </ci>
<ci> TPIKeq </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> TPIKdhap </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> DHAP </ci>
<ci> TPIKdhap </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> GAP </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<apply>
<power/>
<ci> GAP </ci>
<cn type='integer'> 4 </cn>
</apply>
<apply>
<power/>
<ci> TPIKigap </ci>
<cn type='integer'> 4 </cn>
</apply>
</apply>
</apply>
</apply>
<ci> TPIKgap </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='TPP' metaid='metaid_355' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_353' species='T6P' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_354' species='TRH' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> TPPVmax </ci>
<ci> T6P </ci>
</apply>
<apply>
<times/>
<ci> TPPKt6p </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> T6P </ci>
<ci> TPPKt6p </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='TPS' metaid='metaid_360' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_356' species='G6P' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_357' species='UDG' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_358' species='T6P' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_359' species='UDP' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> TPSVmax </ci>
<ci> G6P </ci>
<ci> UDG </ci>
</apply>
<apply>
<times/>
<ci> TPSKg6p </ci>
<ci> TPSKudg </ci>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> G6P </ci>
<ci> TPSKg6p </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type='integer'> 1 </cn>
<apply>
<divide/>
<ci> UDG </ci>
<ci> TPSKudg </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='UGP' metaid='metaid_364' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_361' species='G1P' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_362' species='UTP' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_363' species='UDG' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<divide/>
<apply>
<times/>
<ci> UGPVmax </ci>
<ci> G1P </ci>
<ci> UTP </ci>
</apply>
<apply>
<times/>
<ci> UGPKg1p </ci>
<ci> UGPKutp </ci>
<apply>
<plus/>
<apply>
<divide/>
<ci> UGPKiutp </ci>
<ci> UGPKutp </ci>
</apply>
<apply>
<divide/>
<ci> G1P </ci>
<ci> UGPKg1p </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> UGPKiutp </ci>
<ci> UDG </ci>
</apply>
<apply>
<times/>
<ci> UGPKiudg </ci>
<ci> UGPKutp </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> G1P </ci>
<ci> UDG </ci>
</apply>
<apply>
<times/>
<ci> UGPKg1p </ci>
<ci> UGPKiudg </ci>
</apply>
</apply>
<apply>
<divide/>
<ci> UTP </ci>
<ci> UGPKutp </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> G1P </ci>
<ci> UTP </ci>
</apply>
<apply>
<times/>
<ci> UGPKg1p </ci>
<ci> UGPKutp </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='acetatebranch' metaid='metaid_369' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_365' species='AcAld' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_366' species='NAD' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_367' species='NADH' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_368' species='ACE' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<times/>
<ci> acetatebranchk </ci>
<ci> AcAld </ci>
<ci> NAD </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='succinatebranch' metaid='metaid_374' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_370' species='PYR' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_371' species='NAD' stoichiometry='3'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_372' species='SUC' stoichiometry='0.75'/>
<speciesReference constant='true' metaid='metaid_373' species='NADH' stoichiometry='3'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<times/>
<ci> succinatebranchk </ci>
<ci> NAD </ci>
<ci> PYR </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction fast='false' id='udptoutp' metaid='metaid_379' reversible='true'>
<listOfReactants>
<speciesReference constant='true' metaid='metaid_375' species='ATP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_376' species='UDP' stoichiometry='1'/>
</listOfReactants>
<listOfProducts>
<speciesReference constant='true' metaid='metaid_377' species='ADP' stoichiometry='1'/>
<speciesReference constant='true' metaid='metaid_378' species='UTP' stoichiometry='1'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<times/>
<ci> udptoutpk </ci>
<ci> ATP </ci>
<ci> UDP </ci>
</apply>
</math>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>
Simulation of smallbone18.xml |
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| Notes |
Original model source: in JWS online database.
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| Software | Copasi (www.copasi.org) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| BioModels or JWS Online ID | smallbone18 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Export metadata |
RDF:
metadataModelEntryID39.rdf
XML: metadataModelEntryID39.xml Plain text: metadataModelEntryID39.txt |
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NAD + EtOH
Share
|
Cite Model EntryID 39
Cite Model EntryID 39
| APA |
KiMoSys (https://kimosys.org). (2018, December 21). Model EntryID 39 (Saccharomyces cerevisiae). https://kimosys.org/repository/99/associated_models/39
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| MLA |
KiMoSys (https://kimosys.org). "Model EntryID 39 (Saccharomyces cerevisiae)." 2024, kimosys.org/repository/99/associated_models/39.
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| ISO-690 |
KiMoSys (https://kimosys.org). Model EntryID 39 (Saccharomyces cerevisiae). [online], [Accessed 21 December 2024]. Available from: https://kimosys.org/repository/99/associated_models/39
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| BibTeX |
@misc{ KiMoSysModelEntryID39,
author = "{KiMoSys (https://kimosys.org)}",
title = "Model EntryID 39 (Saccharomyces cerevisiae)",
url = "https://kimosys.org/repository/99/associated_models/39",
note = "[Online; accessed 21-December-2024]"
}
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Related Model(s): AccessID 28 | AccessID 46
Submission and curation
Entered by:
Administrator KiMoSysFirst name: Administrator
Affiliation: INESC-ID/IST
Homepage: http://kdbio.inesc-id.pt/kimosys
Interests: mathematical modeling, accessible data, use of data
Created: 2018-07-16 19:34:20 UTC
Updated: 2018-07-16 19:34:20 UTC
Version: 0
Status: (reviewed) 2018-07-16 19:42:05 UTC
Views: 418
Downloads: 228