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General Information
Manuscript title | Testing Biochemistry Revisited: How In Vivo Metabolism Can Be Understood from In Vitro Enzyme Kinetics |
PubMed ID | 22570597 |
Journal | PLoS Computational Biology |
Year | 2012 |
Authors | Karen van Eunen, José A. L. Kiewiet, Hans V. Westerhoff, Barbara M. Bakker |
Affiliations | Department of Molecular Cell Physiology, VU University Amsterdam, Amsterdam, The Netherlands |
Keywords | yeast glycolysis, In Vivo and in Vitro Enzyme Kinetics, computational model |
Full text article |
vanEunen_2012.pdf |
Project name | not specified |
Data used for | Model building and Model validation |
Model Information
Model name | vanEunen2012 - Yeast Glycolysis (glucose upshift) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Organism | Saccharomyces cerevisiae | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Model type | ordinary differential equations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Category | Metabolism | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of reactions | 17 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of species | 13 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of regulators | not specified | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of parameters | 88 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of compartments | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Dilution rate (h-1) | — | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Model file(s) and history |
LATEST MODEL1403250001.xml
(2018-07-30 22:00:51 UTC
by Administrator KiMoSysFirst name: Administrator Affiliation: INESC-ID/IST Homepage: http://kdbio.inesc-id.pt/kimosys Interests: mathematical modeling, accessible data, use of data ) Preview Preview file MODEL1403250001.xml<?xml version='1.0' encoding='UTF-8'?> <!-- This model was downloaded from BioModels Database --> <!-- http://www.ebi.ac.uk/biomodels-static/ --> <!-- Mon Jul 30 16:38:47 BST 2018 --> <sbml level='2' metaid='_16abc5f3-b97d-4e59-9caa-8fe9d4cb5ebd' version='4' xmlns='http://www.sbml.org/sbml/level2/version4'> <model id='MODEL1403250001' metaid='COPASI1' name='vanEunen2012 - Yeast Glycolysis (glucose upshift)'> <notes> <body xmlns='http://www.w3.org/1999/xhtml'> <pre>This is corresponding to the model of yeast glycolysis "glucose upshift" condition described in the paper "Testing Biochemistry Revisited: How In Vivo Metabolism Can Be Understood from In Vitro Enzyme Kinetics" by van Eunen et al published in Plos Comput Biol, 2012.</pre> </body> </notes> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI1'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:15:11Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> <rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'> <rdf:Description rdf:about='#COPASI1'> <bqmodel:is> <rdf:Bag> <rdf:li rdf:resource='http://identifiers.org/biomodels.db/MODEL1403250001'/> </rdf:Bag> </bqmodel:is> <bqbiol:isVersionOf> <rdf:Bag> <rdf:li rdf:resource='http://www.geneontology.org/GO:0006096'/> </rdf:Bag> </bqbiol:isVersionOf> <bqbiol:hasTaxon> <rdf:Bag> <rdf:li rdf:resource='http://identifiers.org/taxonomy/4932'/> </rdf:Bag> </bqbiol:hasTaxon> </rdf:Description> </rdf:RDF> </annotation> <listOfFunctionDefinitions> <functionDefinition id='function_1' metaid='_2c652719-1ab3-4cdc-b568-aa2bad60ef54' name='Constant flux (irreversible)'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> v </ci> </bvar> <ci> v </ci> </lambda> </math> </functionDefinition> <functionDefinition id='GLT' metaid='COPASI112' name='GLT'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI112'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:27:53Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> Vmax_glt </ci> </bvar> <bvar> <ci> Glco </ci> </bvar> <bvar> <ci> Km_glt_glco </ci> </bvar> <bvar> <ci> Glci </ci> </bvar> <bvar> <ci> Keq_glt </ci> </bvar> <bvar> <ci> Km_glt_glci </ci> </bvar> <bvar> <ci> Ki </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax_glt </ci> <apply> <minus/> <apply> <divide/> <ci> Glco </ci> <ci> Km_glt_glco </ci> </apply> <apply> <divide/> <ci> Glci </ci> <apply> <times/> <ci> Km_glt_glco </ci> <ci> Keq_glt </ci> </apply> </apply> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> Glco </ci> <ci> Km_glt_glco </ci> </apply> <apply> <divide/> <ci> Glci </ci> <ci> Km_glt_glci </ci> </apply> <apply> <divide/> <apply> <times/> <ci> Ki </ci> <ci> Glco </ci> <ci> Glci </ci> </apply> <apply> <times/> <ci> Km_glt_glco </ci> <ci> Km_glt_glci </ci> </apply> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id='HK' metaid='COPASI113' name='HK'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI113'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:45:56Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> Vmax_hk </ci> </bvar> <bvar> <ci> Glci </ci> </bvar> <bvar> <ci> ATP </ci> </bvar> <bvar> <ci> Km_hk_glci </ci> </bvar> <bvar> <ci> Km_hk_atp </ci> </bvar> <bvar> <ci> G6P </ci> </bvar> <bvar> <ci> ADP </ci> </bvar> <bvar> <ci> Keq_hk </ci> </bvar> <bvar> <ci> Km_hk_g6p </ci> </bvar> <bvar> <ci> T6P </ci> </bvar> <bvar> <ci> Ki_hk_t6p </ci> </bvar> <bvar> <ci> Km_hk_adp </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax_hk </ci> <apply> <minus/> <apply> <divide/> <apply> <times/> <ci> Glci </ci> <ci> ATP </ci> </apply> <apply> <times/> <ci> Km_hk_glci </ci> <ci> Km_hk_atp </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> G6P </ci> <ci> ADP </ci> </apply> <apply> <times/> <ci> Km_hk_glci </ci> <ci> Km_hk_atp </ci> <ci> Keq_hk </ci> </apply> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> Glci </ci> <ci> Km_hk_glci </ci> </apply> <apply> <divide/> <ci> G6P </ci> <ci> Km_hk_g6p </ci> </apply> <apply> <divide/> <ci> T6P </ci> <ci> Ki_hk_t6p </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> ATP </ci> <ci> Km_hk_atp </ci> </apply> <apply> <divide/> <ci> ADP </ci> <ci> Km_hk_adp </ci> </apply> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id='PGI' metaid='COPASI114' name='PGI'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI114'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T17:06:17Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> Vmax_pgi </ci> </bvar> <bvar> <ci> G6P </ci> </bvar> <bvar> <ci> Km_pgi_g6p </ci> </bvar> <bvar> <ci> F6P </ci> </bvar> <bvar> <ci> Keq_pgi </ci> </bvar> <bvar> <ci> Km_pgi_f6p </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax_pgi </ci> <apply> <minus/> <apply> <divide/> <ci> G6P </ci> <ci> Km_pgi_g6p </ci> </apply> <apply> <divide/> <ci> F6P </ci> <apply> <times/> <ci> Km_pgi_g6p </ci> <ci> Keq_pgi </ci> </apply> </apply> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> G6P </ci> <ci> Km_pgi_g6p </ci> </apply> <apply> <divide/> <ci> F6P </ci> <ci> Km_pgi_f6p </ci> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id='PFK' metaid='COPASI115' name='PFK'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI115'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T17:40:50Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> Vmax_pfk </ci> </bvar> <bvar> <ci> gR_pfk </ci> </bvar> <bvar> <ci> F6P </ci> </bvar> <bvar> <ci> ATP </ci> </bvar> <bvar> <ci> Km_pfk_f6p </ci> </bvar> <bvar> <ci> Km_pfk_atp </ci> </bvar> <bvar> <ci> L0_pfk </ci> </bvar> <bvar> <ci> Ci_pfk_atp </ci> </bvar> <bvar> <ci> Kpfk_atp </ci> </bvar> <bvar> <ci> Ci_pfk_amp </ci> </bvar> <bvar> <ci> AMP </ci> </bvar> <bvar> <ci> Kpfk_amp </ci> </bvar> <bvar> <ci> Ci_pfk_f26p </ci> </bvar> <bvar> <ci> F26P </ci> </bvar> <bvar> <ci> Kpfk_f26p </ci> </bvar> <bvar> <ci> Ci_pfk_f16p </ci> </bvar> <bvar> <ci> F16P </ci> </bvar> <bvar> <ci> Kpfk_f16p </ci> </bvar> <bvar> <ci> C_atp </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax_pfk </ci> <ci> gR_pfk </ci> <ci> F6P </ci> <ci> ATP </ci> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <apply> <times/> <ci> F6P </ci> <ci> ATP </ci> </apply> <apply> <times/> <ci> Km_pfk_f6p </ci> <ci> Km_pfk_atp </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> gR_pfk </ci> <ci> F6P </ci> <ci> ATP </ci> </apply> <apply> <times/> <ci> Km_pfk_f6p </ci> <ci> Km_pfk_atp </ci> </apply> </apply> </apply> </apply> <apply> <times/> <ci> Km_pfk_f6p </ci> <ci> Km_pfk_atp </ci> <apply> <plus/> <apply> <power/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <apply> <times/> <ci> F6P </ci> <ci> ATP </ci> </apply> <apply> <times/> <ci> Km_pfk_f6p </ci> <ci> Km_pfk_atp </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> gR_pfk </ci> <ci> F6P </ci> <ci> ATP </ci> </apply> <apply> <times/> <ci> Km_pfk_f6p </ci> <ci> Km_pfk_atp </ci> </apply> </apply> </apply> <cn> 2 </cn> </apply> <apply> <times/> <ci> L0_pfk </ci> <apply> <power/> <apply> <divide/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <apply> <times/> <ci> Ci_pfk_atp </ci> <ci> ATP </ci> </apply> <ci> Kpfk_atp </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> ATP </ci> <ci> Kpfk_atp </ci> </apply> </apply> </apply> <cn> 2 </cn> </apply> <apply> <power/> <apply> <divide/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <apply> <times/> <ci> Ci_pfk_amp </ci> <ci> AMP </ci> </apply> <ci> Kpfk_amp </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> AMP </ci> <ci> Kpfk_amp </ci> </apply> </apply> </apply> <cn> 2 </cn> </apply> <apply> <power/> <apply> <divide/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <apply> <times/> <ci> Ci_pfk_f26p </ci> <ci> F26P </ci> </apply> <ci> Kpfk_f26p </ci> </apply> <apply> <divide/> <apply> <times/> <ci> Ci_pfk_f16p </ci> <ci> F16P </ci> </apply> <ci> Kpfk_f16p </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> F26P </ci> <ci> Kpfk_f26p </ci> </apply> <apply> <divide/> <ci> F16P </ci> <ci> Kpfk_f16p </ci> </apply> </apply> </apply> <cn> 2 </cn> </apply> <apply> <power/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <apply> <times/> <ci> C_atp </ci> <ci> ATP </ci> </apply> <ci> Km_pfk_atp </ci> </apply> </apply> <cn> 2 </cn> </apply> </apply> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id='ALD' metaid='COPASI116' name='ALD'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI116'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:15:02Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> Vmax_ald </ci> </bvar> <bvar> <ci> F16P </ci> </bvar> <bvar> <ci> Km_ald_f16p </ci> </bvar> <bvar> <ci> Keq_tpi </ci> </bvar> <bvar> <ci> TRIO </ci> </bvar> <bvar> <ci> Keq_ald </ci> </bvar> <bvar> <ci> Km_ald_gap </ci> </bvar> <bvar> <ci> Km_ald_dhap </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax_ald </ci> <apply> <minus/> <apply> <divide/> <ci> F16P </ci> <ci> Km_ald_f16p </ci> </apply> <apply> <divide/> <apply> <times/> <ci> Keq_tpi </ci> <apply> <power/> <apply> <divide/> <ci> TRIO </ci> <apply> <plus/> <cn> 1 </cn> <ci> Keq_tpi </ci> </apply> </apply> <cn> 2 </cn> </apply> </apply> <apply> <times/> <ci> Km_ald_f16p </ci> <ci> Keq_ald </ci> </apply> </apply> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> F16P </ci> <ci> Km_ald_f16p </ci> </apply> <apply> <divide/> <apply> <divide/> <apply> <times/> <ci> Keq_tpi </ci> <ci> TRIO </ci> </apply> <apply> <plus/> <cn> 1 </cn> <ci> Keq_tpi </ci> </apply> </apply> <ci> Km_ald_gap </ci> </apply> <apply> <divide/> <ci> TRIO </ci> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <ci> Keq_tpi </ci> </apply> <ci> Km_ald_dhap </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> Keq_tpi </ci> <apply> <power/> <apply> <divide/> <ci> TRIO </ci> <apply> <plus/> <cn> 1 </cn> <ci> Keq_tpi </ci> </apply> </apply> <cn> 2 </cn> </apply> </apply> <apply> <times/> <ci> Km_ald_gap </ci> <ci> Km_ald_dhap </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> F16P </ci> <ci> Keq_tpi </ci> <apply> <divide/> <ci> TRIO </ci> <apply> <plus/> <cn> 1 </cn> <ci> Keq_tpi </ci> </apply> </apply> </apply> <apply> <times/> <ci> Km_ald_gap </ci> <ci> Km_ald_f16p </ci> </apply> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id='GAPDH' metaid='COPASI117' name='GAPDH'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI117'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:31:07Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> Vmax_gapdh_f </ci> </bvar> <bvar> <ci> Keq_tpi </ci> </bvar> <bvar> <ci> TRIO </ci> </bvar> <bvar> <ci> NAD </ci> </bvar> <bvar> <ci> Km_gapdh_gap </ci> </bvar> <bvar> <ci> Km_gapdh_nad </ci> </bvar> <bvar> <ci> Vmax_gapdh_r </ci> </bvar> <bvar> <ci> BPG </ci> </bvar> <bvar> <ci> NADH </ci> </bvar> <bvar> <ci> Km_gapdh_bpg </ci> </bvar> <bvar> <ci> Km_gapdh_nadh </ci> </bvar> <apply> <divide/> <apply> <minus/> <apply> <divide/> <apply> <divide/> <apply> <times/> <ci> Vmax_gapdh_f </ci> <ci> Keq_tpi </ci> <ci> TRIO </ci> <ci> NAD </ci> </apply> <apply> <plus/> <cn> 1 </cn> <ci> Keq_tpi </ci> </apply> </apply> <apply> <times/> <ci> Km_gapdh_gap </ci> <ci> Km_gapdh_nad </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> Vmax_gapdh_r </ci> <ci> BPG </ci> <ci> NADH </ci> </apply> <apply> <times/> <ci> Km_gapdh_bpg </ci> <ci> Km_gapdh_nadh </ci> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <apply> <times/> <ci> Keq_tpi </ci> <ci> TRIO </ci> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <ci> Keq_tpi </ci> </apply> <ci> Km_gapdh_gap </ci> </apply> </apply> <apply> <divide/> <ci> BPG </ci> <ci> Km_gapdh_bpg </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> NAD </ci> <ci> Km_gapdh_nad </ci> </apply> <apply> <divide/> <ci> NADH </ci> <ci> Km_gapdh_nadh </ci> </apply> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id='PGK' metaid='COPASI118' name='PGK'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI118'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:37:44Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> Vmax_pgk_r </ci> </bvar> <bvar> <ci> Keq_pgk </ci> </bvar> <bvar> <ci> BPG </ci> </bvar> <bvar> <ci> ADP </ci> </bvar> <bvar> <ci> Km_pgk_p3g </ci> </bvar> <bvar> <ci> Km_pgk_atp </ci> </bvar> <bvar> <ci> P3G </ci> </bvar> <bvar> <ci> ATP </ci> </bvar> <bvar> <ci> Km_pgk_bpg </ci> </bvar> <bvar> <ci> Km_pgk_adp </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax_pgk_r </ci> <apply> <minus/> <apply> <divide/> <apply> <times/> <ci> Keq_pgk </ci> <ci> BPG </ci> <ci> ADP </ci> </apply> <apply> <times/> <ci> Km_pgk_p3g </ci> <ci> Km_pgk_atp </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> P3G </ci> <ci> ATP </ci> </apply> <apply> <times/> <ci> Km_pgk_p3g </ci> <ci> Km_pgk_atp </ci> </apply> </apply> </apply> </apply> <apply> <times/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> BPG </ci> <ci> Km_pgk_bpg </ci> </apply> <apply> <divide/> <ci> P3G </ci> <ci> Km_pgk_p3g </ci> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> ATP </ci> <ci> Km_pgk_atp </ci> </apply> <apply> <divide/> <ci> ADP </ci> <ci> Km_pgk_adp </ci> </apply> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id='GPM' metaid='COPASI119' name='GPM'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI119'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:43:33Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> Vmax_gpm </ci> </bvar> <bvar> <ci> P3G </ci> </bvar> <bvar> <ci> Km_gpm_p3g </ci> </bvar> <bvar> <ci> P2G </ci> </bvar> <bvar> <ci> Keq_gpm </ci> </bvar> <bvar> <ci> Km_gpm_p2g </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax_gpm </ci> <apply> <minus/> <apply> <divide/> <ci> P3G </ci> <ci> Km_gpm_p3g </ci> </apply> <apply> <divide/> <ci> P2G </ci> <apply> <times/> <ci> Km_gpm_p3g </ci> <ci> Keq_gpm </ci> </apply> </apply> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P3G </ci> <ci> Km_gpm_p3g </ci> </apply> <apply> <divide/> <ci> P2G </ci> <ci> Km_gpm_p2g </ci> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id='ENO' metaid='COPASI120' name='ENO'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI120'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:46:05Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> Vmax_eno </ci> </bvar> <bvar> <ci> P2G </ci> </bvar> <bvar> <ci> Km_eno_p2g </ci> </bvar> <bvar> <ci> PEP </ci> </bvar> <bvar> <ci> Keq_eno </ci> </bvar> <bvar> <ci> Km_eno_pep </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax_eno </ci> <apply> <minus/> <apply> <divide/> <ci> P2G </ci> <ci> Km_eno_p2g </ci> </apply> <apply> <divide/> <ci> PEP </ci> <apply> <times/> <ci> Km_eno_p2g </ci> <ci> Keq_eno </ci> </apply> </apply> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> P2G </ci> <ci> Km_eno_p2g </ci> </apply> <apply> <divide/> <ci> PEP </ci> <ci> Km_eno_pep </ci> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id='PYK' metaid='COPASI121' name='PYK'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI121'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:50:44Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> Vmax_pyk </ci> </bvar> <bvar> <ci> PEP </ci> </bvar> <bvar> <ci> Km_pyk_pep </ci> </bvar> <bvar> <ci> n_pyk </ci> </bvar> <bvar> <ci> L0_pyk </ci> </bvar> <bvar> <ci> ATP </ci> </bvar> <bvar> <ci> Km_pyk_atp </ci> </bvar> <bvar> <ci> F16P </ci> </bvar> <bvar> <ci> Km_pyk_f16p </ci> </bvar> <bvar> <ci> ADP </ci> </bvar> <bvar> <ci> Km_pyk_adp </ci> </bvar> <apply> <times/> <apply> <divide/> <apply> <times/> <ci> Vmax_pyk </ci> <apply> <divide/> <ci> PEP </ci> <ci> Km_pyk_pep </ci> </apply> <apply> <power/> <apply> <plus/> <apply> <divide/> <ci> PEP </ci> <ci> Km_pyk_pep </ci> </apply> <cn> 1 </cn> </apply> <apply> <minus/> <ci> n_pyk </ci> <cn> 1 </cn> </apply> </apply> </apply> <apply> <plus/> <apply> <times/> <ci> L0_pyk </ci> <apply> <power/> <apply> <divide/> <apply> <plus/> <apply> <divide/> <ci> ATP </ci> <ci> Km_pyk_atp </ci> </apply> <cn> 1 </cn> </apply> <apply> <plus/> <apply> <divide/> <ci> F16P </ci> <ci> Km_pyk_f16p </ci> </apply> <cn> 1 </cn> </apply> </apply> <ci> n_pyk </ci> </apply> </apply> <apply> <power/> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> PEP </ci> <ci> Km_pyk_pep </ci> </apply> </apply> <ci> n_pyk </ci> </apply> </apply> </apply> <apply> <divide/> <ci> ADP </ci> <apply> <plus/> <ci> ADP </ci> <ci> Km_pyk_adp </ci> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id='PDC' metaid='COPASI122' name='PDC'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI122'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:55:32Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> Vmax_pdc </ci> </bvar> <bvar> <ci> PYR </ci> </bvar> <bvar> <ci> NH_pdc </ci> </bvar> <bvar> <ci> Km_pdc_pyr </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax_pdc </ci> <apply> <power/> <ci> PYR </ci> <ci> NH_pdc </ci> </apply> </apply> <apply> <times/> <ci> Km_pdc_pyr </ci> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <apply> <power/> <ci> PYR </ci> <ci> NH_pdc </ci> </apply> <apply> <power/> <ci> Km_pdc_pyr </ci> <ci> NH_pdc </ci> </apply> </apply> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id='ADH' metaid='COPASI123' name='ADH'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI123'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T13:03:42Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> Vmax_adh_r </ci> </bvar> <bvar> <ci> NADH </ci> </bvar> <bvar> <ci> ACALD </ci> </bvar> <bvar> <ci> Ki_adh_nad </ci> </bvar> <bvar> <ci> Km_adh_etoh </ci> </bvar> <bvar> <ci> Keq_adh </ci> </bvar> <bvar> <ci> NAD </ci> </bvar> <bvar> <ci> ETOH </ci> </bvar> <bvar> <ci> Km_adh_nad </ci> </bvar> <bvar> <ci> Km_adh_nadh </ci> </bvar> <bvar> <ci> Km_adh_acald </ci> </bvar> <bvar> <ci> Ki_adh_nadh </ci> </bvar> <bvar> <ci> Ki_adh_acald </ci> </bvar> <bvar> <ci> Ki_adh_etoh </ci> </bvar> <apply> <divide/> <apply> <times/> <ci> Vmax_adh_r </ci> <apply> <minus/> <apply> <divide/> <apply> <times/> <ci> NADH </ci> <ci> ACALD </ci> </apply> <apply> <times/> <ci> Ki_adh_nad </ci> <ci> Km_adh_etoh </ci> <ci> Keq_adh </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> NAD </ci> <ci> ETOH </ci> </apply> <apply> <times/> <ci> Ki_adh_nad </ci> <ci> Km_adh_etoh </ci> </apply> </apply> </apply> </apply> <apply> <plus/> <cn> 1 </cn> <apply> <divide/> <ci> NAD </ci> <ci> Ki_adh_nad </ci> </apply> <apply> <divide/> <apply> <times/> <ci> Km_adh_nad </ci> <ci> ETOH </ci> </apply> <apply> <times/> <ci> Ki_adh_nad </ci> <ci> Km_adh_etoh </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> Km_adh_nadh </ci> <ci> ACALD </ci> </apply> <apply> <times/> <ci> Ki_adh_nad </ci> <ci> Km_adh_acald </ci> </apply> </apply> <apply> <divide/> <ci> NADH </ci> <ci> Ki_adh_nadh </ci> </apply> <apply> <divide/> <apply> <times/> <ci> NAD </ci> <ci> ETOH </ci> </apply> <apply> <times/> <ci> Ki_adh_nad </ci> <ci> Km_adh_etoh </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> Km_adh_nadh </ci> <ci> NAD </ci> <ci> ACALD </ci> </apply> <apply> <times/> <ci> Ki_adh_nad </ci> <ci> Ki_adh_nadh </ci> <ci> Km_adh_acald </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> Km_adh_nad </ci> <ci> NADH </ci> <ci> ETOH </ci> </apply> <apply> <times/> <ci> Ki_adh_nad </ci> <ci> Ki_adh_nadh </ci> <ci> Km_adh_etoh </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> NADH </ci> <ci> ACALD </ci> </apply> <apply> <times/> <ci> Ki_adh_nadh </ci> <ci> Km_adh_acald </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> NAD </ci> <ci> ETOH </ci> <ci> ACALD </ci> </apply> <apply> <times/> <ci> Ki_adh_nad </ci> <ci> Km_adh_etoh </ci> <ci> Ki_adh_acald </ci> </apply> </apply> <apply> <divide/> <apply> <times/> <ci> NADH </ci> <ci> ETOH </ci> <ci> ACALD </ci> </apply> <apply> <times/> <ci> Ki_adh_etoh </ci> <ci> Ki_adh_nadh </ci> <ci> Km_adh_acald </ci> </apply> </apply> </apply> </apply> </lambda> </math> </functionDefinition> <functionDefinition id='ACE' metaid='COPASI124' name='ACE'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI124'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T13:27:55Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <math xmlns='http://www.w3.org/1998/Math/MathML'> <lambda> <bvar> <ci> K_ace </ci> </bvar> <bvar> <ci> AcAlad </ci> </bvar> <apply> <times/> <ci> K_ace </ci> <ci> AcAlad </ci> </apply> </lambda> </math> </functionDefinition> </listOfFunctionDefinitions> <listOfUnitDefinitions> <unitDefinition id='time' metaid='_3ae24903-619b-4e39-a793-419f892d79b2' name='time'> <listOfUnits> <unit exponent='1' kind='second' metaid='_679ac5ce-cdd9-4732-aa42-9fc7160a0db4' multiplier='60' scale='0'/> </listOfUnits> </unitDefinition> <unitDefinition id='substance' metaid='_5be3ffb9-e878-4f24-9aa2-c270839d910a' name='substance'> <listOfUnits> <unit exponent='1' kind='mole' metaid='c6f2bd13-a942-441c-9443-dd22b765dc9b' multiplier='1' scale='-6'/> </listOfUnits> </unitDefinition> </listOfUnitDefinitions> <listOfCompartments> <compartment constant='true' id='compartment_1' metaid='COPASI2' name='C' size='1' spatialDimensions='3'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI2'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:07:50Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </compartment> </listOfCompartments> <listOfSpecies> <species boundaryCondition='false' compartment='compartment_1' constant='false' hasOnlySubstanceUnits='false' id='species_1' initialConcentration='0.0576023' metaid='COPASI3' name='Glci'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI3'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:51:09Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </species> <species boundaryCondition='false' compartment='compartment_1' constant='false' hasOnlySubstanceUnits='false' id='species_2' initialConcentration='0.121566' metaid='COPASI4' name='G6P'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI4'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:51:33Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </species> <species boundaryCondition='false' compartment='compartment_1' constant='false' hasOnlySubstanceUnits='false' id='species_3' initialConcentration='0.0263653' metaid='COPASI5' name='F6P'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI5'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T17:14:07Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </species> <species boundaryCondition='false' compartment='compartment_1' constant='false' hasOnlySubstanceUnits='false' id='species_4' initialConcentration='0.0928847' metaid='_0225b3a9-65e6-456e-a00e-9b580eda1139' name='F16P'/> <species boundaryCondition='false' compartment='compartment_1' constant='false' hasOnlySubstanceUnits='false' id='species_5' initialConcentration='0.336706' metaid='_97bb4cc5-34fd-44a0-b967-c3418b460976' name='TRIO'/> <species boundaryCondition='false' compartment='compartment_1' constant='false' hasOnlySubstanceUnits='false' id='species_6' initialConcentration='0.000904902' metaid='_6e765938-5d05-4845-b64a-1e887067ddb3' name='BPG'/> <species boundaryCondition='false' compartment='compartment_1' constant='false' hasOnlySubstanceUnits='false' id='species_7' initialConcentration='1.58969' metaid='f383070d-bd3e-48bc-9cb2-cc3858468735' name='NAD'/> <species boundaryCondition='false' compartment='compartment_1' constant='false' hasOnlySubstanceUnits='false' id='species_8' initialConcentration='0.00030978' metaid='_682b091f-a8ac-4f10-a7d5-3d28f25b88e2' name='NADH'/> <species boundaryCondition='false' compartment='compartment_1' constant='false' hasOnlySubstanceUnits='false' id='species_9' initialConcentration='0.945967' metaid='e0a066bc-c54a-4823-99a0-b28bb02332d2' name='P3G'/> <species boundaryCondition='false' compartment='compartment_1' constant='false' hasOnlySubstanceUnits='false' id='species_10' initialConcentration='0.161018' metaid='_304ee170-493d-4679-a002-2f95820d966c' name='P2G'/> <species boundaryCondition='false' compartment='compartment_1' constant='false' hasOnlySubstanceUnits='false' id='species_11' initialConcentration='0.981828' metaid='_818b973d-822f-42cf-8faa-e2b8a2e2cb12' name='PEP'/> <species boundaryCondition='false' compartment='compartment_1' constant='false' hasOnlySubstanceUnits='false' id='species_12' initialConcentration='0.502831' metaid='COPASI6' name='PYR'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI6'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T17:31:56Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </species> <species boundaryCondition='false' compartment='compartment_1' constant='false' hasOnlySubstanceUnits='false' id='species_13' initialConcentration='13' metaid='_438f3a0a-e42b-444a-9944-96cacadc0507' name='AcAld'/> </listOfSpecies> <listOfParameters> <parameter constant='true' id='parameter_1' metaid='COPASI7' name='ETOH' value='25'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI7'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:30:10Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_2' metaid='COPASI8' name='Keq_glt' value='1'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI8'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:31:52Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_3' metaid='COPASI9' name='Km_hk_glci' value='0.08'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI9'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:32:24Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_4' metaid='COPASI10' name='Km_hk_g6p' value='30'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI10'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:33:14Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_5' metaid='COPASI11' name='Km_hk_atp' value='0.15'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI11'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:33:51Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_6' metaid='COPASI12' name='Km_hk_adp' value='0.23'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI12'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:34:53Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_7' metaid='COPASI13' name='Ki_hk_t6p' value='0.04'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI13'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:35:24Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_8' metaid='COPASI14' name='Keq_hk' value='3800'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI14'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:35:58Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_9' metaid='COPASI15' name='Km_pgi_g6p' value='1.4'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI15'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:36:28Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_10' metaid='COPASI16' name='Km_pgi_f6p' value='0.3'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI16'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:37:07Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_11' metaid='COPASI17' name='Keq_pgi' value='0.314'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI17'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:38:05Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_12' metaid='COPASI18' name='gR_pfk' value='5.12'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI18'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:38:46Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_13' metaid='COPASI19' name='L0_pfk' value='0.66'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI19'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:39:23Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_14' metaid='COPASI20' name='Km_pfk_f6p' value='0.1'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI20'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:40:10Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_15' metaid='COPASI21' name='Km_pfk_atp' value='0.71'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI21'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:40:40Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_16' metaid='COPASI22' name='C_atp' value='3'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI22'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:41:12Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_17' metaid='COPASI23' name='Ci_pfk_atp' value='100'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI23'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:41:42Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_18' metaid='COPASI24' name='Ci_pfk_amp' value='0.0845'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI24'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:42:11Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_19' metaid='COPASI25' name='Ci_pfk_f16p' value='0.397'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI25'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:42:45Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_20' metaid='COPASI26' name='Ci_pfk_f26p' value='0.0174'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI26'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:43:30Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_21' metaid='COPASI27' name='Kpfk_atp' value='0.65'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI27'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:44:02Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_22' metaid='COPASI28' name='Kpfk_amp' value='0.0995'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI28'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:44:35Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_23' metaid='COPASI29' name='Kpfk_f16p' value='0.111'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI29'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:46:24Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_24' metaid='COPASI30' name='Kpfk_f26p' value='0.000682'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI30'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:46:57Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_25' metaid='COPASI31' name='Km_ald_f16p' value='0.3'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI31'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:47:33Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_26' metaid='COPASI32' name='Km_ald_dhap' value='2.4'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI32'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:48:07Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_27' metaid='COPASI33' name='Km_ald_gap' value='10'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI33'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:48:36Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_28' metaid='COPASI34' name='Keq_ald' value='0.069'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI34'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:49:07Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_29' metaid='COPASI35' name='Keq_tpi' value='0.045'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI35'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:49:49Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_30' metaid='COPASI36' name='Km_pgk_bpg' value='0.003'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI36'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:50:27Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_31' metaid='COPASI37' name='Km_pgk_p3g' value='0.53'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI37'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:50:59Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_32' metaid='COPASI38' name='Km_pgk_adp' value='0.2'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI38'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:51:30Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_33' metaid='COPASI39' name='Km_pgk_atp' value='0.3'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI39'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:52:00Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_34' metaid='COPASI40' name='Keq_pgk' value='3200'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI40'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:52:30Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_35' metaid='COPASI41' name='Km_gpm_p3g' value='1.2'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI41'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:52:54Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_36' metaid='COPASI42' name='Km_gpm_p2g' value='0.08'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI42'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:53:25Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_37' metaid='COPASI43' name='Keq_gpm' value='0.19'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI43'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:53:54Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_38' metaid='COPASI44' name='Km_eno_p2g' value='0.04'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI44'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:54:25Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_39' metaid='COPASI45' name='Km_eno_pep' value='0.5'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI45'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:54:53Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_40' metaid='COPASI46' name='Keq_eno' value='6.7'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI46'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:55:21Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_41' metaid='COPASI47' name='Km_pyk_adp' value='0.3'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI47'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:56:15Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_42' metaid='COPASI48' name='Km_pyk_pep' value='0.19'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI48'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:55:48Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_43' metaid='COPASI49' name='Km_pyk_atp' value='9.3'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI49'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:56:50Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_44' metaid='COPASI50' name='n_pyk' value='4'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI50'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:57:16Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_45' metaid='COPASI51' name='L0_pyk' value='60000'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI51'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:57:48Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_46' metaid='COPASI52' name='Km_pyk_f16p' value='0.2'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI52'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:58:25Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_47' metaid='COPASI53' name='NH_pdc' value='1.9'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI53'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:59:02Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_48' metaid='COPASI54' name='Km_pdc_pyr' value='6.36'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI54'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:02:31Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_49' metaid='COPASI55' name='Km_adh_acald' value='1.11'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI55'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:03:06Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_50' metaid='COPASI56' name='Km_adh_etoh' value='17'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI56'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:18:30Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_51' metaid='COPASI57' name='Km_adh_nadh' value='0.11'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI57'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:19:06Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_52' metaid='COPASI58' name='Km_adh_nad' value='0.17'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI58'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:19:38Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_53' metaid='COPASI59' name='Ki_adh_acald' value='1.1'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI59'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:20:14Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_54' metaid='COPASI60' name='Ki_adh_etoh' value='90'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI60'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:20:45Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_55' metaid='COPASI61' name='Ki_adh_nadh' value='0.031'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI61'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:21:22Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_56' metaid='COPASI62' name='Ki_adh_nad' value='0.92'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI62'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:21:56Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_57' metaid='COPASI63' name='Keq_adh' value='6.9e-05'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI63'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:22:28Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_58' metaid='COPASI64' name='Vmax_glt' value='160'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI64'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:23:05Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_59' metaid='COPASI65' name='Km_glt_glco' value='1'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI65'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:23:38Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_60' metaid='COPASI66' name='Km_glt_glci' value='1'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI66'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:24:07Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_61' metaid='COPASI67' name='Ki' value='0.75'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI67'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:24:51Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_62' metaid='COPASI68' name='Vmax_hk' value='213'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI68'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:25:20Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_63' metaid='COPASI69' name='Vmax_pgi' value='787'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI69'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:26:08Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_64' metaid='COPASI70' name='Vmax_pfk' value='213'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI70'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:26:42Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_65' metaid='COPASI71' name='Vmax_ald' value='310'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI71'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:27:14Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_66' metaid='COPASI72' name='Vmax_gapdh_f' value='1487'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI72'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:27:49Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_67' metaid='COPASI73' name='Vmax_gapdh_r' value='853'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI73'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:28:29Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_68' metaid='COPASI74' name='Km_gapdh_gap' value='0.39'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI74'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:29:10Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_69' metaid='COPASI75' name='Km_gapdh_nad' value='2.85'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI75'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:29:42Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_70' metaid='COPASI76' name='Km_gapdh_nadh' value='0.007'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI76'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:30:19Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_71' metaid='COPASI77' name='Km_gapdh_bpg' value='0.51'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI77'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:30:53Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_72' metaid='COPASI78' name='Vmax_pgk_r' value='2512'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI78'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:31:26Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_73' metaid='COPASI79' name='Vmax_gpm' value='856'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI79'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:32:00Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_74' metaid='COPASI80' name='Vmax_eno' value='357'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI80'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:32:35Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_75' metaid='COPASI81' name='Vmax_pyk' value='820'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI81'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:33:33Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_76' metaid='COPASI82' name='Vmax_pdc' value='395'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI82'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:34:06Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_77' metaid='COPASI83' name='Vmax_adh_r' value='932'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI83'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:34:38Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_78' metaid='COPASI84' name='ADP' value='1'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI84'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:35:08Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_79' metaid='COPASI85' name='AMP' value='0.3'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI85'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:35:44Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_80' metaid='COPASI86' name='T6P' value='0.2'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI86'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:36:08Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_81' metaid='COPASI87' name='F26P' value='0.014'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI87'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:36:38Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_82' metaid='COPASI88' name='Glco' value='5'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI88'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:38:11Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_83' metaid='COPASI89' name='ATP' value='1.5'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI89'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:39:05Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_84' metaid='COPASI90' name='K_tre1' value='0'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI90'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T17:00:19Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_85' metaid='COPASI91' name='K_tre2' value='0'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI91'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T17:01:14Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_86' metaid='COPASI92' name='K_gly' value='17.5'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI92'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T17:01:39Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_87' metaid='COPASI93' name='K_suc' value='0.9'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI93'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T17:02:17Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> <parameter constant='true' id='parameter_88' metaid='COPASI94' name='K_ace' value='0.5'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI94'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T17:02:43Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> </parameter> </listOfParameters> <listOfReactions> <reaction id='reaction_1' metaid='COPASI95' name='Glt' reversible='true'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI95'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T15:25:00Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfProducts> <speciesReference metaid='_39916b18-32fe-437b-8153-b03f0201e2f8' species='species_1' stoichiometry='1'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid='_2c5d1145-0996-415c-9506-59a611b43ea3' species='species_1'/> <modifierSpeciesReference species='species_1'/> </listOfModifiers> <kineticLaw metaid='feb9c8ff-3fb9-48af-b306-2158f02a1624'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> GLT </ci> <ci> parameter_58 </ci> <ci> parameter_82 </ci> <ci> parameter_59 </ci> <ci> species_1 </ci> <ci> parameter_2 </ci> <ci> parameter_60 </ci> <ci> parameter_61 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_2' metaid='COPASI96' name='Hk' reversible='true'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI96'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:45:02Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='e7896445-7e1f-458a-90b0-e1e5101ec90a' species='species_1' stoichiometry='1'/> </listOfReactants> <listOfProducts> <speciesReference metaid='a574f936-f38e-4a79-9ec4-9282238915f5' species='species_2' stoichiometry='1'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid='d598bd75-4ee7-4d37-9216-057fce645f2b' species='species_1'/> <modifierSpeciesReference metaid='_2d1389cd-1583-4afa-8d5a-3cc14746e6b4' species='species_2'/> <modifierSpeciesReference species='species_1'/> <modifierSpeciesReference species='species_2'/> </listOfModifiers> <kineticLaw metaid='cb55202b-c805-46be-996f-13b072e5e09e'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> HK </ci> <ci> parameter_62 </ci> <ci> species_1 </ci> <ci> parameter_83 </ci> <ci> parameter_3 </ci> <ci> parameter_5 </ci> <ci> species_2 </ci> <ci> parameter_78 </ci> <ci> parameter_8 </ci> <ci> parameter_4 </ci> <ci> parameter_80 </ci> <ci> parameter_7 </ci> <ci> parameter_6 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_3' metaid='COPASI97' name='Tre1' reversible='false'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI97'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T16:58:03Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfProducts> <speciesReference metaid='_17c82421-3920-47c3-8b1f-f16d9075b963' species='species_1' stoichiometry='2'/> </listOfProducts> <kineticLaw metaid='ec7de378-404b-45ea-b3d4-c148d34c3e7f'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_1 </ci> <ci> parameter_84 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_4' metaid='COPASI98' name='Tre2' reversible='false'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI98'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T17:03:55Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='f17a4c15-2922-47dd-92e9-8376474afd5f' species='species_2' stoichiometry='2'/> </listOfReactants> <kineticLaw metaid='ac8b46d2-f1ae-4de7-aaa8-409043df038f'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_1 </ci> <ci> parameter_85 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_5' metaid='COPASI99' name='PGI' reversible='true'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI99'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T17:04:51Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='_03e67f5d-efe1-4ac5-a60b-ba108f02758b' species='species_2' stoichiometry='1'/> </listOfReactants> <listOfProducts> <speciesReference metaid='efe68b36-fb79-41c5-a443-3a93c44b0adf' species='species_3' stoichiometry='1'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid='bdbef24f-1cf8-401f-9949-0bb9111724e0' species='species_2'/> <modifierSpeciesReference metaid='_368acb50-29e5-4db7-bf1a-7388a750cbb8' species='species_3'/> <modifierSpeciesReference species='species_2'/> <modifierSpeciesReference species='species_3'/> </listOfModifiers> <kineticLaw metaid='a8367d9b-a210-4dc3-aab6-91ffc907bdfe'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> PGI </ci> <ci> parameter_63 </ci> <ci> species_2 </ci> <ci> parameter_9 </ci> <ci> species_3 </ci> <ci> parameter_11 </ci> <ci> parameter_10 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_6' metaid='COPASI100' name='Pfk' reversible='false'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI100'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-06T17:40:13Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='_960e4ef5-39d2-400b-a244-6952cd7ab37d' species='species_3' stoichiometry='1'/> </listOfReactants> <listOfProducts> <speciesReference metaid='_2c29e34d-8581-4462-99ce-ee95ea06b8d5' species='species_4' stoichiometry='1'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid='_2682d158-6c58-4622-8a5d-23fee08d22d4' species='species_3'/> <modifierSpeciesReference metaid='ad40bab6-d58b-4bf9-bb91-992d118abe04' species='species_4'/> <modifierSpeciesReference species='species_3'/> <modifierSpeciesReference species='species_4'/> </listOfModifiers> <kineticLaw metaid='_5d9617bf-82e5-4d2f-8955-3ca95eb91484'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> PFK </ci> <ci> parameter_64 </ci> <ci> parameter_12 </ci> <ci> species_3 </ci> <ci> parameter_83 </ci> <ci> parameter_14 </ci> <ci> parameter_15 </ci> <ci> parameter_13 </ci> <ci> parameter_17 </ci> <ci> parameter_21 </ci> <ci> parameter_18 </ci> <ci> parameter_79 </ci> <ci> parameter_22 </ci> <ci> parameter_20 </ci> <ci> parameter_81 </ci> <ci> parameter_24 </ci> <ci> parameter_19 </ci> <ci> species_4 </ci> <ci> parameter_23 </ci> <ci> parameter_16 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_7' metaid='COPASI101' name='Ald' reversible='true'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI101'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:08:44Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='c91f3ff6-2b2a-4046-a09e-29bf1747bc9b' species='species_4' stoichiometry='1'/> </listOfReactants> <listOfProducts> <speciesReference metaid='_4850ff00-ee2b-45ec-b704-c8ace7385f35' species='species_5' stoichiometry='2'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid='a9217d7d-5db2-4c74-8f3f-29b957862e34' species='species_4'/> <modifierSpeciesReference metaid='ff330de1-e68d-4617-91b7-5d636c3b9392' species='species_5'/> <modifierSpeciesReference species='species_4'/> <modifierSpeciesReference species='species_5'/> </listOfModifiers> <kineticLaw metaid='_7732b305-855e-4e23-b357-d9b01d868319'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> ALD </ci> <ci> parameter_65 </ci> <ci> species_4 </ci> <ci> parameter_25 </ci> <ci> parameter_29 </ci> <ci> species_5 </ci> <ci> parameter_28 </ci> <ci> parameter_27 </ci> <ci> parameter_26 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_8' metaid='COPASI102' name='Gapdh' reversible='true'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI102'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:25:00Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='_4e22451e-c1b8-43e0-9363-3b06bb2dfcbe' species='species_5' stoichiometry='1'/> <speciesReference metaid='_7d91d9a4-420c-437c-8e74-12ceb4a60a40' species='species_7' stoichiometry='1'/> </listOfReactants> <listOfProducts> <speciesReference metaid='_1a0b6f0b-c19b-46ed-bd4c-85d6156e0e70' species='species_6' stoichiometry='1'/> <speciesReference metaid='fbc874ee-e1c6-4da3-ab35-590fad450798' species='species_8' stoichiometry='1'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid='af62b867-0869-4a4d-87c1-f36df58c2694' species='species_5'/> <modifierSpeciesReference metaid='_3468ae3b-9e06-42c1-905a-26f5909f9c79' species='species_7'/> <modifierSpeciesReference metaid='c4f652a6-8496-42c0-8dda-a08e46a36920' species='species_6'/> <modifierSpeciesReference metaid='_4a5576ff-9abf-4a99-b474-4acbb075a0d7' species='species_8'/> <modifierSpeciesReference species='species_5'/> <modifierSpeciesReference species='species_7'/> <modifierSpeciesReference species='species_6'/> <modifierSpeciesReference species='species_8'/> </listOfModifiers> <kineticLaw metaid='cb070eb2-f852-4899-842c-8b7032de1c2d'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> GAPDH </ci> <ci> parameter_66 </ci> <ci> parameter_29 </ci> <ci> species_5 </ci> <ci> species_7 </ci> <ci> parameter_68 </ci> <ci> parameter_69 </ci> <ci> parameter_67 </ci> <ci> species_6 </ci> <ci> species_8 </ci> <ci> parameter_71 </ci> <ci> parameter_70 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_9' metaid='COPASI103' name='Gly' reversible='false'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI103'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:34:14Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='a2bc9aa5-cd97-4af3-a05c-58e358092919' species='species_5' stoichiometry='1'/> <speciesReference metaid='_48b8fff9-d051-4dd8-b206-d67447c14093' species='species_8' stoichiometry='1'/> </listOfReactants> <listOfProducts> <speciesReference metaid='_81150686-d732-4fe0-ad5d-38cbf85fbbf7' species='species_7' stoichiometry='1'/> </listOfProducts> <kineticLaw metaid='_02c6fea1-58b6-403f-95c1-c20772846a54'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_1 </ci> <ci> parameter_86 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_10' metaid='COPASI104' name='Pgk' reversible='true'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI104'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:36:50Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='ebbbf309-2705-4e17-810d-1417fc5fe0f7' species='species_6' stoichiometry='1'/> </listOfReactants> <listOfProducts> <speciesReference metaid='c4804be5-524c-43a8-85f8-4e4dc8fac530' species='species_9' stoichiometry='1'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid='fa1f67b8-e1d8-4b46-9bdf-bef1a8d7dbae' species='species_6'/> <modifierSpeciesReference metaid='_740ef861-4f2e-461f-b516-8012643863cc' species='species_9'/> <modifierSpeciesReference species='species_6'/> <modifierSpeciesReference species='species_9'/> </listOfModifiers> <kineticLaw metaid='_6d7cd61e-1fb4-4d75-8c1d-366e798eabed'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> PGK </ci> <ci> parameter_72 </ci> <ci> parameter_34 </ci> <ci> species_6 </ci> <ci> parameter_78 </ci> <ci> parameter_31 </ci> <ci> parameter_33 </ci> <ci> species_9 </ci> <ci> parameter_83 </ci> <ci> parameter_30 </ci> <ci> parameter_32 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_11' metaid='COPASI105' name='Gpm' reversible='true'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI105'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:42:57Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='e3e543b2-cc55-46f3-8b07-f68e94346e3f' species='species_9' stoichiometry='1'/> </listOfReactants> <listOfProducts> <speciesReference metaid='_87865873-eeaf-40c6-9a75-a2f827bfa97d' species='species_10' stoichiometry='1'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid='_29f89090-d33e-4b71-93ec-22768bd638a8' species='species_9'/> <modifierSpeciesReference metaid='_59bdcd3d-043a-4b01-a28c-b27c58c1d97c' species='species_10'/> <modifierSpeciesReference species='species_9'/> <modifierSpeciesReference species='species_10'/> </listOfModifiers> <kineticLaw metaid='_2ec263a8-804d-4657-87be-2f44a415a6df'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> GPM </ci> <ci> parameter_73 </ci> <ci> species_9 </ci> <ci> parameter_35 </ci> <ci> species_10 </ci> <ci> parameter_37 </ci> <ci> parameter_36 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_12' metaid='COPASI106' name='Eno' reversible='true'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI106'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:45:43Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='_06d8e2a4-b4da-4bc7-96a5-6ef6658a29a7' species='species_10' stoichiometry='1'/> </listOfReactants> <listOfProducts> <speciesReference metaid='_776755a5-27f5-4093-b774-9d6973a04db8' species='species_11' stoichiometry='1'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid='_0e544306-d1a5-45c2-9e9a-4d71f916ebf3' species='species_10'/> <modifierSpeciesReference metaid='_50bd1590-4e73-4022-801f-06e23f720d06' species='species_11'/> <modifierSpeciesReference species='species_10'/> <modifierSpeciesReference species='species_11'/> </listOfModifiers> <kineticLaw metaid='_848cf00b-84fa-45d1-a630-92a739d4f5c4'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> ENO </ci> <ci> parameter_74 </ci> <ci> species_10 </ci> <ci> parameter_38 </ci> <ci> species_11 </ci> <ci> parameter_40 </ci> <ci> parameter_39 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_13' metaid='COPASI107' name='Pyk' reversible='false'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI107'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:50:22Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='_66145b3d-ec33-4704-b928-89fd31c6d094' species='species_11' stoichiometry='1'/> </listOfReactants> <listOfProducts> <speciesReference metaid='_5e764ef3-5019-412d-b5c0-784ec2d75d3b' species='species_12' stoichiometry='1'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid='_21f2645b-a70f-4ecd-9d5f-fb48fdad3469' species='species_4'/> <modifierSpeciesReference metaid='_0feda53c-af58-4726-9577-46ee07fb4a0a' species='species_11'/> <modifierSpeciesReference metaid='fc61d078-70e6-452b-a4c5-2ba4799484df' species='species_4'/> <modifierSpeciesReference species='species_11'/> <modifierSpeciesReference species='species_4'/> </listOfModifiers> <kineticLaw metaid='d119846c-4c4d-4c15-a502-e9dbd94fab89'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> PYK </ci> <ci> parameter_75 </ci> <ci> species_11 </ci> <ci> parameter_42 </ci> <ci> parameter_44 </ci> <ci> parameter_45 </ci> <ci> parameter_83 </ci> <ci> parameter_43 </ci> <ci> species_4 </ci> <ci> parameter_46 </ci> <ci> parameter_78 </ci> <ci> parameter_41 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_14' metaid='COPASI108' name='Pdc' reversible='false'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI108'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:54:58Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='_5929fbf4-2bb7-4bfb-aea6-79a639b91692' species='species_12' stoichiometry='1'/> </listOfReactants> <listOfProducts> <speciesReference metaid='c94d5b01-562a-466e-876f-4e9031728664' species='species_13' stoichiometry='1'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid='_2bf7df96-c39c-48fa-bb8c-1017979f8590' species='species_12'/> <modifierSpeciesReference species='species_12'/> </listOfModifiers> <kineticLaw metaid='e7e7b0fc-9e6c-4293-b138-97f384132d1c'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> PDC </ci> <ci> parameter_76 </ci> <ci> species_12 </ci> <ci> parameter_47 </ci> <ci> parameter_48 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_15' metaid='COPASI109' name='Suc' reversible='false'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI109'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T12:59:32Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='_47b549c5-dc89-414e-b75c-aece5b4fc530' species='species_12' stoichiometry='2'/> <speciesReference metaid='_58a5e01b-06a7-4642-8b4e-b7c7cf6eb00a' species='species_7' stoichiometry='3'/> </listOfReactants> <listOfProducts> <speciesReference metaid='_016a671a-aec9-426d-9eda-660ca59a05d6' species='species_8' stoichiometry='3'/> </listOfProducts> <kineticLaw metaid='af381762-4a37-4b73-883f-3bd8b9cfe104'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> function_1 </ci> <ci> parameter_87 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_16' metaid='COPASI110' name='Ace' reversible='false'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI110'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T13:01:34Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='c7c84d23-027f-40a4-aa8d-d9e9fc328a7e' species='species_13' stoichiometry='1'/> <speciesReference metaid='_6d4c5a3a-fb5a-4d17-83a3-15104261d62f' species='species_7' stoichiometry='1'/> </listOfReactants> <listOfProducts> <speciesReference metaid='_1e971021-bb72-44b2-b25c-37d675caced4' species='species_8' stoichiometry='1'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid='f7f74f98-bd9e-45ee-b398-ecaee5a8dadd' species='species_13'/> <modifierSpeciesReference species='species_13'/> </listOfModifiers> <kineticLaw metaid='_2d006a0a-5695-4bb4-883c-ef12776c4584'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> ACE </ci> <ci> parameter_88 </ci> <ci> species_13 </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='reaction_17' metaid='COPASI111' name='Adh' reversible='true'> <annotation> <COPASI xmlns='http://www.copasi.org/static/sbml'> <rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'> <rdf:Description rdf:about='#COPASI111'> <dcterms:created> <rdf:Description> <dcterms:W3CDTF>2014-03-07T13:02:48Z</dcterms:W3CDTF> </rdf:Description> </dcterms:created> </rdf:Description> </rdf:RDF> </COPASI> </annotation> <listOfReactants> <speciesReference metaid='_326b7699-cdb2-4a69-a3e0-8462816c39f0' species='species_8' stoichiometry='1'/> <speciesReference metaid='d9f59b4a-fd24-45ea-80e1-ee4760597959' species='species_13' stoichiometry='1'/> </listOfReactants> <listOfProducts> <speciesReference metaid='_51b335b8-0787-40ba-8065-cfeb881263a2' species='species_7' stoichiometry='1'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference metaid='_9f9ec8ef-9516-45df-bc04-95684d9a5b87' species='species_8'/> <modifierSpeciesReference metaid='_37e514e1-ca93-4931-be28-047beab1e752' species='species_13'/> <modifierSpeciesReference metaid='_5bc11203-4a05-47d9-a377-9c14816ff509' species='species_7'/> <modifierSpeciesReference species='species_8'/> <modifierSpeciesReference species='species_13'/> <modifierSpeciesReference species='species_7'/> </listOfModifiers> <kineticLaw metaid='f1f52c91-ef93-4184-9b74-8036d29e027e'> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> compartment_1 </ci> <apply> <ci> ADH </ci> <ci> parameter_77 </ci> <ci> species_8 </ci> <ci> species_13 </ci> <ci> parameter_56 </ci> <ci> parameter_50 </ci> <ci> parameter_57 </ci> <ci> species_7 </ci> <ci> parameter_1 </ci> <ci> parameter_52 </ci> <ci> parameter_51 </ci> <ci> parameter_49 </ci> <ci> parameter_55 </ci> <ci> parameter_53 </ci> <ci> parameter_54 </ci> </apply> </apply> </math> </kineticLaw> </reaction> </listOfReactions> </model> </sbml>
Simulation of MODEL1403250001.xml |
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Notes |
Original model source: in BioModels database.
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Software | MATLAB (MathWorks) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
BioModels or JWS Online ID | BIOMD1403250001 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Export metadata |
RDF:
metadataModelEntryID46.rdf
XML: metadataModelEntryID46.xml Plain text: metadataModelEntryID46.txt |
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Share
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Cite Model EntryID 46
Cite Model EntryID 46
APA |
KiMoSys (https://kimosys.org). (2018, October 12). Model EntryID 46 (Saccharomyces cerevisiae). https://kimosys.org/repository/111/associated_models/46
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MLA |
KiMoSys (https://kimosys.org). "Model EntryID 46 (Saccharomyces cerevisiae)." 2024, kimosys.org/repository/111/associated_models/46.
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ISO-690 |
KiMoSys (https://kimosys.org). Model EntryID 46 (Saccharomyces cerevisiae). [online], [Accessed 12 October 2024]. Available from: https://kimosys.org/repository/111/associated_models/46
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BibTeX |
@misc{ KiMoSysModelEntryID46,
author = "{KiMoSys (https://kimosys.org)}",
title = "Model EntryID 46 (Saccharomyces cerevisiae)",
url = "https://kimosys.org/repository/111/associated_models/46",
note = "[Online; accessed 12-October-2024]"
}
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Related Model(s): AccessID 28 | AccessID 39
Entered by:
Administrator KiMoSysFirst name: Administrator
Affiliation: INESC-ID/IST
Homepage: http://kdbio.inesc-id.pt/kimosys
Interests: mathematical modeling, accessible data, use of data
Created: 2018-07-30 22:00:51 UTC
Updated: 2018-07-30 22:06:01 UTC
Version: 0
Status: (reviewed) 2018-07-30 22:05:01 UTC
Views: 141
Downloads: 64