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General Information
Manuscript title | Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. |
PubMed ID | 21772264 |
Journal | Molecular Systems Biology |
Year | 2011 |
Authors | Julie Bachmann, Andreas Raue, Marcel Schilling, Martin E. Boehm, Clemens Kreutz, Daniel Kaschek, Hauke Busch, Norbert Gretz, Wolf D. Lehmann, Jens Timmer and Ursula Klingmueller |
Affiliations | Division of Systems Biology of Signal Transduction, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany |
Keywords | apoptosis, erythropoietin, mathematical modeling, negative feedback, SOCS, simulation and data analysis, signal transduction |
Full text article |
Bachmann_2011.pdf |
Project name | not specified |
Data used for | Model building |
Model Information
Model name | transcriptional model of JAK2/STAT5 signaling | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Organism | Mouse | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Model type | ordinary differential equations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Category | Signal | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of reactions | 36 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of species | 25 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of regulators | not specified | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of parameters | 115 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of compartments | 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Dilution rate (h-1) | — | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Model file(s) and history |
LATEST KIMOMODEL31.xml
(2014-04-23 17:30:03 UTC
by Administrator KiMoSys
)
Preview
Preview file KIMOMODEL31.xml<?xml version='1.0' encoding='UTF-8'?> <sbml level='2' version='1' xmlns='http://www.sbml.org/sbml/level2'> <model id='jak2_stat5_feedbacks' name='jak2_stat5_feedbacks'> <notes> <body xmlns='http://www.w3.org/1999/xhtml'> <p>SBML model Bachmann et al.</p> </body> </notes> <listOfCompartments> <compartment constant='true' id='cyt' name='cyt' size='0.4' spatialDimensions='3'/> <compartment constant='true' id='nuc' name='nuc' size='0.275' spatialDimensions='3'/> </listOfCompartments> <listOfSpecies> <species compartment='cyt' id='EpoRJAK2' initialConcentration='3.97622' name='EpoRJAK2'> </species> <species compartment='cyt' id='EpoRpJAK2' initialConcentration='0' name='EpoRpJAK2'> </species> <species compartment='cyt' id='p1EpoRpJAK2' initialConcentration='0' name='p1EpoRpJAK2'> </species> <species compartment='cyt' id='p2EpoRpJAK2' initialConcentration='0' name='p2EpoRpJAK2'> </species> <species compartment='cyt' id='p12EpoRpJAK2' initialConcentration='0' name='p12EpoRpJAK2'> </species> <species compartment='cyt' id='EpoRJAK2_CIS' initialConcentration='0' name='EpoRJAK2_CIS'> </species> <species compartment='cyt' id='SHP1' initialConcentration='26.7251' name='SHP1'> </species> <species compartment='cyt' id='SHP1Act' initialConcentration='0' name='SHP1Act'> </species> <species compartment='cyt' id='STAT5' initialConcentration='79.7535' name='STAT5'> </species> <species compartment='cyt' id='pSTAT5' initialConcentration='0' name='pSTAT5'> </species> <species compartment='nuc' id='npSTAT5' initialConcentration='0' name='npSTAT5'> </species> <species compartment='nuc' id='CISnRNA1' initialConcentration='0' name='CISnRNA1'> </species> <species compartment='nuc' id='CISnRNA2' initialConcentration='0' name='CISnRNA2'> </species> <species compartment='nuc' id='CISnRNA3' initialConcentration='0' name='CISnRNA3'> </species> <species compartment='nuc' id='CISnRNA4' initialConcentration='0' name='CISnRNA4'> </species> <species compartment='nuc' id='CISnRNA5' initialConcentration='0' name='CISnRNA5'> </species> <species compartment='cyt' id='CISRNA' initialConcentration='0' name='CISRNA'> </species> <species compartment='cyt' id='CIS' initialConcentration='0' name='CIS'> </species> <species compartment='nuc' id='SOCS3nRNA1' initialConcentration='0' name='SOCS3nRNA1'> </species> <species compartment='nuc' id='SOCS3nRNA2' initialConcentration='0' name='SOCS3nRNA2'> </species> <species compartment='nuc' id='SOCS3nRNA3' initialConcentration='0' name='SOCS3nRNA3'> </species> <species compartment='nuc' id='SOCS3nRNA4' initialConcentration='0' name='SOCS3nRNA4'> </species> <species compartment='nuc' id='SOCS3nRNA5' initialConcentration='0' name='SOCS3nRNA5'> </species> <species compartment='cyt' id='SOCS3RNA' initialConcentration='0' name='SOCS3RNA'> </species> <species compartment='cyt' id='SOCS3' initialConcentration='0' name='SOCS3'> </species> <species compartment='cyt' id='Epo' initialConcentration='1.24997e-007' name='Epo'> </species> </listOfSpecies> <listOfParameters> <parameter id='ActD' value='0'/> <parameter id='CISEqc' value='432.871'/> <parameter id='CISEqcOE' value='0.530261'/> <parameter id='CISInh' value='7.84653e+008'/> <parameter id='CISRNADelay' value='0.144775'/> <parameter id='CISRNAEqc' value='1'/> <parameter id='CISRNATurn' value='1000'/> <parameter id='CISTurn' value='0.00839842'/> <parameter id='CISoe' value='0'/> <parameter id='EpoRActJAK2' value='0.267308'/> <parameter id='EpoRCISInh' value='1e+006'/> <parameter id='EpoRCISRemove' value='5.42932'/> <parameter id='JAK2ActEpo' value='633253'/> <parameter id='JAK2EpoRDeaSHP1' value='142.722'/> <parameter id='SHP1ActEpoR' value='0.001'/> <parameter id='SHP1Dea' value='0.00816391'/> <parameter id='SOCS3Eqc' value='173.653'/> <parameter id='SOCS3EqcOE' value='0.679157'/> <parameter id='SOCS3Inh' value='10.408'/> <parameter id='SOCS3RNADelay' value='1.06465'/> <parameter id='SOCS3RNAEqc' value='1'/> <parameter id='SOCS3RNATurn' value='0.00830844'/> <parameter id='SOCS3Turn' value='10000'/> <parameter id='SOCS3oe' value='0'/> <parameter id='STAT5ActEpoR' value='38.9757'/> <parameter id='STAT5ActJAK2' value='0.0780965'/> <parameter id='STAT5Exp' value='0.0745155'/> <parameter id='STAT5Imp' value='0.0268889'/> <parameter id='epo_level' value='1.24997e-007'/> <parameter id='init_EpoRJAK2' value='3.97622'/> <parameter id='init_SHP1' value='26.7251'/> <parameter id='init_STAT5' value='79.7535'/> </listOfParameters> <listOfReactions> <reaction id='reaction_1' reversible='false'> <listOfReactants> <speciesReference species='EpoRJAK2'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='EpoRpJAK2'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='Epo'> </modifierSpeciesReference> <modifierSpeciesReference species='SOCS3'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><apply><times/><ci>JAK2ActEpo</ci><ci>Epo</ci></apply><ci>EpoRJAK2</ci></apply><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_2' reversible='false'> <listOfReactants> <speciesReference species='EpoRpJAK2'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='EpoRJAK2'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='SHP1Act'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><apply><times/><ci>JAK2EpoRDeaSHP1</ci><ci>SHP1Act</ci></apply><ci>EpoRpJAK2</ci></apply><ci>init_SHP1</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_3' reversible='false'> <listOfReactants> <speciesReference species='EpoRpJAK2'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='p1EpoRpJAK2'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='SOCS3'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><ci>EpoRActJAK2</ci><ci>EpoRpJAK2</ci></apply><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_4' reversible='false'> <listOfReactants> <speciesReference species='EpoRpJAK2'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='p2EpoRpJAK2'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='EpoRJAK2_CIS'> </modifierSpeciesReference> <modifierSpeciesReference species='SOCS3'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><apply><times/><cn>3</cn><ci>EpoRActJAK2</ci></apply><ci>EpoRpJAK2</ci></apply><apply><times/><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply><apply><plus/><apply><times/><ci>EpoRCISInh</ci><ci>EpoRJAK2_CIS</ci></apply><cn>1</cn></apply></apply></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_5' reversible='false'> <listOfReactants> <speciesReference species='p1EpoRpJAK2'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='p12EpoRpJAK2'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='EpoRJAK2_CIS'> </modifierSpeciesReference> <modifierSpeciesReference species='SOCS3'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><apply><times/><cn>3</cn><ci>EpoRActJAK2</ci></apply><ci>p1EpoRpJAK2</ci></apply><apply><times/><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply><apply><plus/><apply><times/><ci>EpoRCISInh</ci><ci>EpoRJAK2_CIS</ci></apply><cn>1</cn></apply></apply></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_6' reversible='false'> <listOfReactants> <speciesReference species='p2EpoRpJAK2'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='p12EpoRpJAK2'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='SOCS3'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><ci>EpoRActJAK2</ci><ci>p2EpoRpJAK2</ci></apply><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_7' reversible='false'> <listOfReactants> <speciesReference species='p1EpoRpJAK2'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='EpoRJAK2'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='SHP1Act'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><apply><times/><ci>JAK2EpoRDeaSHP1</ci><ci>SHP1Act</ci></apply><ci>p1EpoRpJAK2</ci></apply><ci>init_SHP1</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_8' reversible='false'> <listOfReactants> <speciesReference species='p2EpoRpJAK2'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='EpoRJAK2'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='SHP1Act'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><apply><times/><ci>JAK2EpoRDeaSHP1</ci><ci>SHP1Act</ci></apply><ci>p2EpoRpJAK2</ci></apply><ci>init_SHP1</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_9' reversible='false'> <listOfReactants> <speciesReference species='p12EpoRpJAK2'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='EpoRJAK2'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='SHP1Act'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><apply><times/><ci>JAK2EpoRDeaSHP1</ci><ci>SHP1Act</ci></apply><ci>p12EpoRpJAK2</ci></apply><ci>init_SHP1</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_10' reversible='false'> <listOfReactants> <speciesReference species='EpoRJAK2_CIS'> </speciesReference> </listOfReactants> <listOfModifiers> <modifierSpeciesReference species='p12EpoRpJAK2'> </modifierSpeciesReference> <modifierSpeciesReference species='p1EpoRpJAK2'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><apply><times/><ci>EpoRCISRemove</ci><ci>EpoRJAK2_CIS</ci></apply><apply><plus/><ci>p12EpoRpJAK2</ci><ci>p1EpoRpJAK2</ci></apply></apply><ci>init_EpoRJAK2</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_11' reversible='false'> <listOfReactants> <speciesReference species='SHP1'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='SHP1Act'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='EpoRpJAK2'> </modifierSpeciesReference> <modifierSpeciesReference species='p12EpoRpJAK2'> </modifierSpeciesReference> <modifierSpeciesReference species='p1EpoRpJAK2'> </modifierSpeciesReference> <modifierSpeciesReference species='p2EpoRpJAK2'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><apply><times/><ci>SHP1ActEpoR</ci><ci>SHP1</ci></apply><apply><plus/><apply><plus/><apply><plus/><ci>EpoRpJAK2</ci><ci>p12EpoRpJAK2</ci></apply><ci>p1EpoRpJAK2</ci></apply><ci>p2EpoRpJAK2</ci></apply></apply><ci>init_EpoRJAK2</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_12' reversible='false'> <listOfReactants> <speciesReference species='SHP1Act'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='SHP1'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>SHP1Dea</ci><ci>SHP1Act</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_13' reversible='false'> <listOfReactants> <speciesReference species='STAT5'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='pSTAT5'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='EpoRpJAK2'> </modifierSpeciesReference> <modifierSpeciesReference species='SOCS3'> </modifierSpeciesReference> <modifierSpeciesReference species='p12EpoRpJAK2'> </modifierSpeciesReference> <modifierSpeciesReference species='p1EpoRpJAK2'> </modifierSpeciesReference> <modifierSpeciesReference species='p2EpoRpJAK2'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><apply><times/><ci>STAT5ActJAK2</ci><ci>STAT5</ci></apply><apply><plus/><apply><plus/><apply><plus/><ci>EpoRpJAK2</ci><ci>p12EpoRpJAK2</ci></apply><ci>p1EpoRpJAK2</ci></apply><ci>p2EpoRpJAK2</ci></apply></apply><apply><times/><ci>init_EpoRJAK2</ci><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply></apply></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_14' reversible='false'> <listOfReactants> <speciesReference species='STAT5'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='pSTAT5'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='CIS'> </modifierSpeciesReference> <modifierSpeciesReference species='SOCS3'> </modifierSpeciesReference> <modifierSpeciesReference species='p12EpoRpJAK2'> </modifierSpeciesReference> <modifierSpeciesReference species='p1EpoRpJAK2'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><apply><times/><ci>STAT5ActEpoR</ci><ci>STAT5</ci></apply><apply><power/><apply><plus/><ci>p12EpoRpJAK2</ci><ci>p1EpoRpJAK2</ci></apply><cn>2</cn></apply></apply><apply><times/><apply><times/><apply><power/><ci>init_EpoRJAK2</ci><cn>2</cn></apply><apply><plus/><apply><divide/><apply><times/><ci>CISInh</ci><ci>CIS</ci></apply><ci>CISEqc</ci></apply><cn>1</cn></apply></apply><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply></apply></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_15' reversible='false'> <listOfReactants> <speciesReference species='pSTAT5'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='npSTAT5'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>STAT5Imp</ci><ci>pSTAT5</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_16' reversible='false'> <listOfReactants> <speciesReference species='npSTAT5'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='STAT5'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>STAT5Exp</ci><ci>npSTAT5</ci></apply><ci>nuc</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_17' reversible='true'> <listOfProducts> <speciesReference species='CISnRNA1'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='npSTAT5'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><minus/><apply><times/><apply><divide/><apply><times/><apply><times/><apply><times/><ci>CISRNAEqc</ci><ci>CISRNATurn</ci></apply><ci>npSTAT5</ci></apply><apply><minus/><ci>ActD</ci><cn>1</cn></apply></apply><ci>init_STAT5</ci></apply><ci>nuc</ci></apply></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_18' reversible='false'> <listOfReactants> <speciesReference species='CISnRNA1'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='CISnRNA2'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>CISRNADelay</ci><ci>CISnRNA1</ci></apply><ci>nuc</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_19' reversible='false'> <listOfReactants> <speciesReference species='CISnRNA2'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='CISnRNA3'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>CISRNADelay</ci><ci>CISnRNA2</ci></apply><ci>nuc</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_20' reversible='false'> <listOfReactants> <speciesReference species='CISnRNA3'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='CISnRNA4'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>CISRNADelay</ci><ci>CISnRNA3</ci></apply><ci>nuc</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_21' reversible='false'> <listOfReactants> <speciesReference species='CISnRNA4'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='CISnRNA5'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>CISRNADelay</ci><ci>CISnRNA4</ci></apply><ci>nuc</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_22' reversible='false'> <listOfReactants> <speciesReference species='CISnRNA5'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='CISRNA'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>CISRNADelay</ci><ci>CISnRNA5</ci></apply><ci>nuc</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_23' reversible='false'> <listOfReactants> <speciesReference species='CISRNA'> </speciesReference> </listOfReactants> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>CISRNATurn</ci><ci>CISRNA</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_24' reversible='false'> <listOfProducts> <speciesReference species='CIS'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='CISRNA'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><apply><times/><ci>CISEqc</ci><ci>CISTurn</ci></apply><ci>CISRNA</ci></apply><ci>CISRNAEqc</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_25' reversible='false'> <listOfReactants> <speciesReference species='CIS'> </speciesReference> </listOfReactants> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>CISTurn</ci><ci>CIS</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_26' reversible='false'> <listOfProducts> <speciesReference species='CIS'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><apply><times/><ci>CISoe</ci><ci>CISEqc</ci></apply><ci>CISTurn</ci></apply><ci>CISEqcOE</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_27' reversible='true'> <listOfProducts> <speciesReference species='SOCS3nRNA1'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='npSTAT5'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><minus/><apply><times/><apply><divide/><apply><times/><apply><times/><apply><times/><ci>SOCS3RNAEqc</ci><ci>SOCS3RNATurn</ci></apply><ci>npSTAT5</ci></apply><apply><minus/><ci>ActD</ci><cn>1</cn></apply></apply><ci>init_STAT5</ci></apply><ci>nuc</ci></apply></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_28' reversible='false'> <listOfReactants> <speciesReference species='SOCS3nRNA1'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='SOCS3nRNA2'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>SOCS3RNADelay</ci><ci>SOCS3nRNA1</ci></apply><ci>nuc</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_29' reversible='false'> <listOfReactants> <speciesReference species='SOCS3nRNA2'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='SOCS3nRNA3'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>SOCS3RNADelay</ci><ci>SOCS3nRNA2</ci></apply><ci>nuc</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_30' reversible='false'> <listOfReactants> <speciesReference species='SOCS3nRNA3'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='SOCS3nRNA4'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>SOCS3RNADelay</ci><ci>SOCS3nRNA3</ci></apply><ci>nuc</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_31' reversible='false'> <listOfReactants> <speciesReference species='SOCS3nRNA4'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='SOCS3nRNA5'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>SOCS3RNADelay</ci><ci>SOCS3nRNA4</ci></apply><ci>nuc</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_32' reversible='false'> <listOfReactants> <speciesReference species='SOCS3nRNA5'> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference species='SOCS3RNA'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>SOCS3RNADelay</ci><ci>SOCS3nRNA5</ci></apply><ci>nuc</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_33' reversible='false'> <listOfReactants> <speciesReference species='SOCS3RNA'> </speciesReference> </listOfReactants> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>SOCS3RNATurn</ci><ci>SOCS3RNA</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_34' reversible='false'> <listOfProducts> <speciesReference species='SOCS3'> </speciesReference> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='SOCS3RNA'> </modifierSpeciesReference> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><divide/><apply><times/><apply><times/><ci>SOCS3Eqc</ci><ci>SOCS3Turn</ci></apply><ci>SOCS3RNA</ci></apply><ci>SOCS3RNAEqc</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_35' reversible='false'> <listOfReactants> <speciesReference species='SOCS3'> </speciesReference> </listOfReactants> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><ci>SOCS3Turn</ci><ci>SOCS3</ci></apply><ci>cyt</ci></apply> </math> </kineticLaw> </reaction> <reaction id='reaction_36' reversible='false'> <listOfProducts> <speciesReference species='SOCS3'> </speciesReference> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply><times/><apply><times/><apply><times/><ci>SOCS3oe</ci><ci>SOCS3Eqc</ci></apply><ci>SOCS3Turn</ci></apply><ci>SOCS3EqcOE</ci></apply> </math> </kineticLaw> </reaction> </listOfReactions> </model> </sbml>
Simulation of KIMOMODEL31.xml |
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Notes |
not specified
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Software | http://www.matlab.com (MATLAB) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
BioModels or JWS Online ID | — | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Export metadata |
RDF:
metadataModelEntryID31.rdf
XML: metadataModelEntryID31.xml Plain text: metadataModelEntryID31.txt |
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Share
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Cite Model EntryID 31
Cite Model EntryID 31
APA |
KiMoSys (https://kimosys.org). (2014, October 12). Model EntryID 31 (Mus musculus). https://kimosys.org/repository/81/associated_models/31
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MLA |
KiMoSys (https://kimosys.org). "Model EntryID 31 (Mus musculus)." 2024, kimosys.org/repository/81/associated_models/31.
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ISO-690 |
KiMoSys (https://kimosys.org). Model EntryID 31 (Mus musculus). [online], [Accessed 12 October 2024]. Available from: https://kimosys.org/repository/81/associated_models/31
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BibTeX |
@misc{ KiMoSysModelEntryID31,
author = "{KiMoSys (https://kimosys.org)}",
title = "Model EntryID 31 (Mus musculus)",
url = "https://kimosys.org/repository/81/associated_models/31",
note = "[Online; accessed 12-October-2024]"
}
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Entered by:
Administrator KiMoSysFirst name: Administrator
Affiliation: INESC-ID/IST
Homepage: http://kdbio.inesc-id.pt/kimosys
Interests: mathematical modeling, accessible data, use of data
Created: 2014-04-23 17:30:03 UTC
Updated: 2014-06-30 17:59:26 UTC
Version: 0
Status: (reviewed) 2018-07-14 21:23:00 UTC
Views: 161
Downloads: 54