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General Information
Manuscript title | A systems biology approach to investigate the effect of pH-induced gene regulation on solvent production by Clostridium acetobutylicum in continuous culture. |
PubMed ID | 21247470 |
Journal | BMC Systems Biology |
Year | 2011 |
Authors | Sylvia Haus, Sara Jabbari, Thomas Millat, Holger Janssen, Ralf-Jörg Fischer, Hubert Bahl, John R King, Olaf Wolkenhauer |
Affiliations | University of Rostock, Institute of Computer Science, Department of Systems Biology & Bioinformatics |
Keywords | Clostridium acetobutylicum, continuous culture, effect of pH, solvent production |
Full text article |
Haus_2011.pdf |
Project name | not specified |
Data used for | Model building |
Model Information
Model name | third forward shift | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Organism | Clostridium acetobutylicum | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Model type | ordinary differential equations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Category | Metabolism | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of reactions | 13 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of species | 12 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of regulators | not specified | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of parameters | 26 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of compartments | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Dilution rate (h-1) | 0.1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Model file(s) and history |
LATEST KIMOMODELID21.xml
(2014-04-11 17:24:43 UTC
by Administrator KiMoSys
)
Preview
Preview file KIMOMODELID21.xml<?xml version='1.0' encoding='UTF-8'?> <!-- Created by JWS2SBML on 2010/10/08 16:38:37--> <!-- A Systems Biology Approach to Investigate the Effect of pH-induced Gene Regulation on Solvent Production by Clostridium acetobutylicum in Continuous Culture Sylvia Haus, Sara Jabbari, Thomas Millat, Holger Janssen, Ralf-Jörg Fischer, Hubert Bahl, John King, Olaf Wolkenhauer BMC Systems Biology (2010) Corresponding author: Sara Jabbari sara.jabbari@nottingham.ac.uk --> <sbml level='2' version='4' xmlns='http://www.sbml.org/sbml/level2/version4'> <model name='pH_shift_forward_3'> <listOfCompartments> <compartment id='compartment' name='compartment' size='1'/> </listOfCompartments> <listOfSpecies> <species boundaryCondition='true' compartment='compartment' constant='true' id='extVariable' initialConcentration='0' name='extVariable'/> <species compartment='compartment' id='AC' initialConcentration='0' name='AC'/> <species compartment='compartment' id='A' initialConcentration='18.15' name='A'/> <species compartment='compartment' id='AaC' initialConcentration='0' name='AaC'/> <species compartment='compartment' id='Aa' initialConcentration='0' name='Aa'/> <species compartment='compartment' id='En' initialConcentration='9.64' name='En'/> <species compartment='compartment' id='B' initialConcentration='48.37' name='B'/> <species compartment='compartment' id='BC' initialConcentration='0' name='BC'/> <species compartment='compartment' id='An' initialConcentration='2.15' name='An'/> <species compartment='compartment' id='Bn' initialConcentration='2.39' name='Bn'/> <species compartment='compartment' id='Ad' initialConcentration='0' name='Ad'/> <species compartment='compartment' id='Cf' initialConcentration='0' name='Cf'/> <species compartment='compartment' id='Ah' initialConcentration='0' name='Ah'/> </listOfSpecies> <listOfParameters> <parameter id='k0' name='k0' value='0'/> <parameter id='G' name='G' value='40'/> <parameter id='Dvar' name='Dvar' value='0.075'/> <parameter id='V1' name='V1' value='4.94'/> <parameter id='V2' name='V2' value='2.92'/> <parameter id='V4' name='V4' value='22.8'/> <parameter id='V8' name='V8' value='64.8'/> <parameter id='V10' name='V10' value='4.75'/> <parameter id='K1' name='K1' value='0.00158'/> <parameter id='K2' name='K2' value='0.00181'/> <parameter id='K4' name='K4' value='1.87'/> <parameter id='K8' name='K8' value='7.92e-06'/> <parameter id='K10' name='K10' value='1.4e-05'/> <parameter id='alpha3' name='alpha3' value='0.00517'/> <parameter id='alpha5' name='alpha5' value='0.014'/> <parameter id='alpha6' name='alpha6' value='0.00537'/> <parameter id='alpha7' name='alpha7' value='4790'/> <parameter id='alpha9' name='alpha9' value='347000'/> <parameter id='rAd' name='rAd' value='0.00547'/> <parameter id='rCf' name='rCf' value='0.000324'/> <parameter id='rAh' name='rAh' value='0.289'/> <parameter id='rAdplus' name='rAdplus' value='0.1037'/> <parameter id='rCfplus' name='rCfplus' value='1.063'/> <parameter id='rAhplus' name='rAhplus' value='2.5594'/> <parameter id='n' name='n' value='485'/> <parameter id='pstar' name='pstar' value='4.5'/> <parameter id='Chemostat' name='Chemostat' value='1'/> </listOfParameters> <listOfReactions> <reaction id='_1' name='v1'> <listOfReactants> <speciesReference species='extVariable'/> </listOfReactants> <listOfProducts> <speciesReference species='AC'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <divide/> <apply> <times/> <cn type='integer'> 2 </cn> <ci> V1 </ci> <ci> G </ci> </apply> <apply> <plus/> <ci> K1 </ci> <ci> G </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='_2' name='v2'> <listOfReactants> <speciesReference species='AC'/> </listOfReactants> <listOfProducts> <speciesReference species='A'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <divide/> <apply> <times/> <ci> V2 </ci> <ci> AC </ci> </apply> <apply> <plus/> <ci> K2 </ci> <ci> AC </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='_3' name='v3'> <listOfReactants> <speciesReference species='A'/> <speciesReference species='AaC'/> </listOfReactants> <listOfProducts> <speciesReference species='AC'/> <speciesReference species='Aa'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='Cf'/> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> alpha3 </ci> <ci> A </ci> <ci> AaC </ci> <ci> Cf </ci> </apply> </math> </kineticLaw> </reaction> <reaction id='_4' name='v4'> <listOfReactants> <speciesReference species='AC'/> </listOfReactants> <listOfProducts> <speciesReference species='AaC'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <divide/> <apply> <times/> <ci> V4 </ci> <ci> AC </ci> </apply> <apply> <plus/> <ci> K4 </ci> <ci> AC </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='_5' name='v5'> <listOfReactants> <speciesReference species='AC'/> </listOfReactants> <listOfProducts> <speciesReference species='En'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='Ah'/> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> alpha5 </ci> <ci> AC </ci> <ci> Ah </ci> </apply> </math> </kineticLaw> </reaction> <reaction id='_6' name='v6'> <listOfReactants> <speciesReference species='AaC'/> <speciesReference species='B'/> </listOfReactants> <listOfProducts> <speciesReference species='Aa'/> <speciesReference species='BC'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='Cf'/> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> alpha6 </ci> <ci> B </ci> <ci> AaC </ci> <ci> Cf </ci> </apply> </math> </kineticLaw> </reaction> <reaction id='_7' name='v7'> <listOfReactants> <speciesReference species='Aa'/> </listOfReactants> <listOfProducts> <speciesReference species='An'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='Ad'/> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> alpha7 </ci> <ci> Aa </ci> <ci> Ad </ci> </apply> </math> </kineticLaw> </reaction> <reaction id='_8' name='v8'> <listOfReactants> <speciesReference species='BC'/> </listOfReactants> <listOfProducts> <speciesReference species='B'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <divide/> <apply> <times/> <ci> V8 </ci> <ci> BC </ci> </apply> <apply> <plus/> <ci> K8 </ci> <ci> BC </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='_9' name='v9'> <listOfReactants> <speciesReference species='BC'/> </listOfReactants> <listOfProducts> <speciesReference species='Bn'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='Ah'/> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> alpha9 </ci> <ci> BC </ci> <ci> Ah </ci> </apply> </math> </kineticLaw> </reaction> <reaction id='_10' name='v10'> <listOfReactants> <speciesReference species='extVariable'/> </listOfReactants> <listOfProducts> <speciesReference species='Ad'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='Tanh'/> <modifierSpeciesReference species='t'/> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <minus/> <apply> <plus/> <ci> rAd </ci> <apply> <times/> <ci> rAdplus </ci> <apply> <minus/> <cn type='integer'> 1 </cn> <apply> <tanh/> <apply> <times/> <ci> n </ci> <apply> <minus/> <apply> <plus/> <apply> <minus/> <cn> 5.7 </cn> <apply> <times/> <cn> 0.6 </cn> <apply> <tanh/> <apply> <times/> <cn> 126.7953 </cn> <cn> 0.1477 </cn> </apply> </apply> </apply> </apply> <apply> <times/> <cn> 0.6 </cn> <apply> <tanh/> <apply> <times/> <cn> -0.1477 </cn> <apply> <minus/> <ci> t </ci> <cn> 126.7953 </cn> </apply> </apply> </apply> </apply> </apply> <ci> pstar </ci> </apply> </apply> </apply> </apply> </apply> </apply> <apply> <times/> <ci> Dvar </ci> <ci> Ad </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='_11' name='v11'> <listOfReactants> <speciesReference species='extVariable'/> </listOfReactants> <listOfProducts> <speciesReference species='Cf'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='Tanh'/> <modifierSpeciesReference species='t'/> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <minus/> <apply> <plus/> <ci> rCf </ci> <apply> <times/> <ci> rCfplus </ci> <apply> <minus/> <cn type='integer'> 1 </cn> <apply> <tanh/> <apply> <times/> <ci> n </ci> <apply> <minus/> <apply> <plus/> <apply> <minus/> <cn> 5.7 </cn> <apply> <times/> <cn> 0.6 </cn> <apply> <tanh/> <apply> <times/> <cn> 126.7953 </cn> <cn> 0.1477 </cn> </apply> </apply> </apply> </apply> <apply> <times/> <cn> 0.6 </cn> <apply> <tanh/> <apply> <times/> <cn> -0.1477 </cn> <apply> <minus/> <ci> t </ci> <cn> 126.7953 </cn> </apply> </apply> </apply> </apply> </apply> <ci> pstar </ci> </apply> </apply> </apply> </apply> </apply> </apply> <apply> <times/> <ci> Dvar </ci> <ci> Cf </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='_12' name='v12'> <listOfReactants> <speciesReference species='extVariable'/> </listOfReactants> <listOfProducts> <speciesReference species='Ah'/> </listOfProducts> <listOfModifiers> <modifierSpeciesReference species='Tanh'/> <modifierSpeciesReference species='t'/> </listOfModifiers> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <minus/> <apply> <plus/> <ci> rAh </ci> <apply> <times/> <ci> rAhplus </ci> <apply> <minus/> <cn type='integer'> 1 </cn> <apply> <tanh/> <apply> <times/> <ci> n </ci> <apply> <minus/> <apply> <plus/> <apply> <minus/> <cn> 5.7 </cn> <apply> <times/> <cn> 0.6 </cn> <apply> <tanh/> <apply> <times/> <cn> 126.7953 </cn> <cn> 0.1477 </cn> </apply> </apply> </apply> </apply> <apply> <times/> <cn> 0.6 </cn> <apply> <tanh/> <apply> <times/> <cn> -0.1477 </cn> <apply> <minus/> <ci> t </ci> <cn> 126.7953 </cn> </apply> </apply> </apply> </apply> </apply> <ci> pstar </ci> </apply> </apply> </apply> </apply> </apply> </apply> <apply> <times/> <ci> Dvar </ci> <ci> Ah </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='_13' name='v13'> <listOfReactants> <speciesReference species='AaC'/> </listOfReactants> <listOfProducts> <speciesReference species='BC'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <divide/> <apply> <times/> <ci> V10 </ci> <ci> AaC </ci> </apply> <apply> <plus/> <ci> K10 </ci> <ci> AaC </ci> </apply> </apply> </math> </kineticLaw> </reaction> <reaction id='_14' name='v14'> <listOfReactants> <speciesReference species='AC'/> </listOfReactants> <listOfProducts> <speciesReference species='extVariable'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> Dvar </ci> <ci> AC </ci> </apply> </math> </kineticLaw> </reaction> <reaction id='_15' name='v15'> <listOfReactants> <speciesReference species='A'/> </listOfReactants> <listOfProducts> <speciesReference species='extVariable'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> Dvar </ci> <ci> A </ci> </apply> </math> </kineticLaw> </reaction> <reaction id='_16' name='v16'> <listOfReactants> <speciesReference species='En'/> </listOfReactants> <listOfProducts> <speciesReference species='extVariable'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> Dvar </ci> <ci> En </ci> </apply> </math> </kineticLaw> </reaction> <reaction id='_17' name='v17'> <listOfReactants> <speciesReference species='AaC'/> </listOfReactants> <listOfProducts> <speciesReference species='extVariable'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> Dvar </ci> <ci> AaC </ci> </apply> </math> </kineticLaw> </reaction> <reaction id='_18' name='v18'> <listOfReactants> <speciesReference species='Aa'/> </listOfReactants> <listOfProducts> <speciesReference species='extVariable'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> Dvar </ci> <ci> Aa </ci> </apply> </math> </kineticLaw> </reaction> <reaction id='_19' name='v19'> <listOfReactants> <speciesReference species='BC'/> </listOfReactants> <listOfProducts> <speciesReference species='extVariable'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> Dvar </ci> <ci> BC </ci> </apply> </math> </kineticLaw> </reaction> <reaction id='_20' name='v20'> <listOfReactants> <speciesReference species='B'/> </listOfReactants> <listOfProducts> <speciesReference species='extVariable'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> Dvar </ci> <ci> B </ci> </apply> </math> </kineticLaw> </reaction> <reaction id='_21' name='v21'> <listOfReactants> <speciesReference species='An'/> </listOfReactants> <listOfProducts> <speciesReference species='extVariable'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> Dvar </ci> <ci> An </ci> </apply> </math> </kineticLaw> </reaction> <reaction id='_22' name='v22'> <listOfReactants> <speciesReference species='Bn'/> </listOfReactants> <listOfProducts> <speciesReference species='extVariable'/> </listOfProducts> <kineticLaw> <math xmlns='http://www.w3.org/1998/Math/MathML'> <apply> <times/> <ci> Dvar </ci> <ci> Bn </ci> </apply> </math> </kineticLaw> </reaction> </listOfReactions> </model></sbml>
Simulation of KIMOMODELID21.xml |
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Notes |
not specified
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Software | http://www.sbtoolbox.org (SBToolbox) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
BioModels or JWS Online ID | — | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Export metadata |
RDF:
metadataModelEntryID21.rdf
XML: metadataModelEntryID21.xml Plain text: metadataModelEntryID21.txt |
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Share
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Cite Model EntryID 21
Cite Model EntryID 21
APA |
KiMoSys (https://kimosys.org). (2018, December 21). Model EntryID 21 (Clostridium acetobutylicum). https://kimosys.org/repository/42/associated_models/21
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MLA |
KiMoSys (https://kimosys.org). "Model EntryID 21 (Clostridium acetobutylicum)." 2024, kimosys.org/repository/42/associated_models/21.
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ISO-690 |
KiMoSys (https://kimosys.org). Model EntryID 21 (Clostridium acetobutylicum). [online], [Accessed 21 December 2024]. Available from: https://kimosys.org/repository/42/associated_models/21
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BibTeX |
@misc{ KiMoSysModelEntryID21,
author = "{KiMoSys (https://kimosys.org)}",
title = "Model EntryID 21 (Clostridium acetobutylicum)",
url = "https://kimosys.org/repository/42/associated_models/21",
note = "[Online; accessed 21-December-2024]"
}
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Related Model(s): AccessID 19 | AccessID 20 | AccessID 22
Entered by:
Administrator KiMoSysFirst name: Administrator
Affiliation: INESC-ID/IST
Homepage: http://kdbio.inesc-id.pt/kimosys
Interests: mathematical modeling, accessible data, use of data
Created: 2013-05-03 13:31:42 UTC
Updated: 2018-07-21 14:50:56 UTC
Version: 0
Status: (reviewed) 2013-12-06 18:05:51 UTC
Views: 205
Downloads: 67